HFR Cartridge and Inflammation (HFR)
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|ClinicalTrials.gov Identifier: NCT01865773|
Recruitment Status : Completed
First Posted : May 31, 2013
Last Update Posted : May 31, 2013
|Condition or disease||Intervention/treatment||Phase|
|Inflammatory Status P-cresol||Procedure: HFR dialysis||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||8 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Role of HFR Cartridge in the Removal of Mediators of Inflammation and P-cresol in Hemodialysis Patients|
|Study Start Date :||January 2011|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||September 2012|
We selected 8 inflamed chronic HD patients, which underwent a single 240 minutes HFR session
Procedure: HFR dialysis
HFR is a dialysis technique that combines the processes of diffusion, convection and adsorption. In this double chamber hemodiafiltration system, the ultrafiltrate is reinfused after its passage (and opportune modification) through a resin cartridge.
Other Name: hmodiafiltration with on line reinfusion of ultrafiltrate
- IL-6 removal by a single session of HFR-Supra [ Time Frame: The evaluation will be performed for the duration of a single HFR session of 240 minutes ]We studied the change in IL-6 circulating levels, by comparing pre- and post-HFR serum concentrations. In addition, we compared IL-6 levels in the UF entering (UFin) and exiting (UFout) from the cartridge, either at the start or at the end of the HFR session. The proinflammatory activity of UFin and UFout was determined by evaluating the changes that they induced in IL-6 mRNA expression and release in peripheral blood mononuclear cells (PBMC) collected from 8 healthy volunteers and cultured in vitro for 24 hr.
- P-cresol removal by a single HFR session [ Time Frame: The evaluation will be performed for the duration of a single HFR session of 240 minutes ]We studied the change in p-cresol circulating levels, by comparing pre- and post-HFR serum concentrations. In addition, we compared p-cresol levels in the UF entering (UFin) and exiting (UFout) from the cartridge, either at the start or at the end of the HFR session.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01865773
|federico II university, department of nephrology|
|Naples, Italy, 80129|