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Use of TpCO2 (Transcutaneous CO2 Measurement) as PaCO2 Predictor During NIV in Case of Acute Hypercapnic Respiratory Failure (TpCO2-NIV)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01857635
Recruitment Status : Completed
First Posted : May 20, 2013
Last Update Posted : June 9, 2015
Information provided by (Responsible Party):
Prof. Philippe Jolliet, University of Lausanne Hospitals

Brief Summary:
In patients suffering from hypercapnic respiratory failure and treated by non invasive ventilation (NIV), the interest of using transcutaneous CO2 measurement to evaluate PaCO2 and PaCO2 variation over time is unknown and will be evaluated in this study. Measurements will be done during one-hour NIV treatments.

Condition or disease
Hypercapnic Respiratory Failure

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Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Use of TpCO2 (Transcutaneous CO2 Measurement)as PaCO2 Predictor During Non Invasive Ventilation (NIV) in Case of Acute Hypercapnic Respiratory Failure
Study Start Date : February 2013
Actual Primary Completion Date : March 2015
Actual Study Completion Date : March 2015

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Comparison between TpCO2 (transcutaneous non invasive CO2 partial pressure measurement) and PaCO2 (obtained by blood gas analysis) values during NIV treatment. [ Time Frame: sixty minutes ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Intensive care unit patients equipped with an arterial line and requiring non invasive ventilation because of acute hypercapnic respiratory failure

Inclusion Criteria:

  • ICU patient equipped with an arterial line
  • NIV treatment prescribed by the clinician in charge
  • Hypercapnia defined by PaCO2> 42mmHg

Exclusion Criteria:

  • Severe hemodynamic instability
  • Severe psychiatric disorders
  • Denied consent
  • Age < 18 years

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01857635

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Intensive care and burn unit, University hospital of Lausanne
Lausanne, Switzerland, 1011
Sponsors and Collaborators
University of Lausanne Hospitals
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Principal Investigator: Philippe Jolliet, Prof University of Lausanne Hospitals
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Responsible Party: Prof. Philippe Jolliet, Principal investigator, University of Lausanne Hospitals Identifier: NCT01857635    
Other Study ID Numbers: TpCO2-NIV
First Posted: May 20, 2013    Key Record Dates
Last Update Posted: June 9, 2015
Last Verified: June 2015
Keywords provided by Prof. Philippe Jolliet, University of Lausanne Hospitals:
Acute respiratory failure
Non invasive ventilation
Transcutaneous CO2 measurement
Additional relevant MeSH terms:
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Respiratory Insufficiency
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms