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Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage

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ClinicalTrials.gov Identifier: NCT01853904
Recruitment Status : Completed
First Posted : May 15, 2013
Last Update Posted : January 7, 2014
Sponsor:
Information provided by (Responsible Party):
University of Oklahoma

Brief Summary:

Bronchoalveolar lavage (BAL) is a common technique among pulmonologists. Its goal is to collect cells from alveolar units. This is done by wedging a flexible bronchoscope in a bronchus, instilling saline, and removing the saline via suction. Two techniques are currently used for suctioning: syringe based and channel suction.

The investigators concern is that channel suction creates too much force and there is collapsing of the airways which results in decreased fluid removal as well as cell sampling. The investigators propose that syringe based suctioning will not only return more of the instilled fluid but also more cells from the alveoli.


Condition or disease Intervention/treatment Phase
Bronchoscopy Procedure: Bronchoscopy/ BAL with Channel Suction Procedure: Bronchoscopy/BAL with Syringe Suction Not Applicable

Detailed Description:
The pulmonary segment with the most disease on imaging will be the segment sampled. The scope will be wedged in the airway leading to that segment and 100mL of saline will be instilled into the selected segment and collected via the syringe based or channel based suction. Prior to unwedging, another 100mL of saline will be instilled into the same segment and will be collected using the alternative method. There will not be randomization, but the investigators will alternate which method is used first to eliminate confounding variables. All patients will receive both modalities of suctioning. The wall suction used for the channel suction will be set at 80 mm Hg. Syringe based suctioning will be performed with 20mL syringe. Total amount of fluid collected will be recorded and samples will be sent for cell count and differential as well as Gram stain and culture. Results of the two techniques will then be compared to determine which is the superior suctioning modality for BAL.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Utility of Syringe Based Suction Versus Channel Suction in Bronchoalveolar Lavage
Study Start Date : July 2012
Actual Primary Completion Date : June 2013
Actual Study Completion Date : August 2013

Arm Intervention/treatment
Channel Suction first
This arm is for patients who will receive channel suction first to obtain the specimen then syringe suction to obtain the specimen.
Procedure: Bronchoscopy/ BAL with Channel Suction
The wall suction used for the channel suction will be set at 80 mm Hg. This arm is for patients who will receive channel suction first to obtain the specimen then syringe suction to obtain the specimen.

Procedure: Bronchoscopy/BAL with Syringe Suction
Syringe based suctioning will be performed with 20mL syringe.

Syringe Suction first
This arm is for patients who will receive syringe suction first to obtain the specimen then channel suction to obtain the specimen.
Procedure: Bronchoscopy/ BAL with Channel Suction
The wall suction used for the channel suction will be set at 80 mm Hg. This arm is for patients who will receive channel suction first to obtain the specimen then syringe suction to obtain the specimen.

Procedure: Bronchoscopy/BAL with Syringe Suction
Syringe based suctioning will be performed with 20mL syringe.




Primary Outcome Measures :
  1. Efficacy of Syringe Suction versus Channel Suction to retrieve volume [ Time Frame: 24 hours ]

Secondary Outcome Measures :
  1. Efficacy of Syringe suction versus Channel suction to retrieve alveolar cells [ Time Frame: 24 hours ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Bronchoscopy scheduled

Exclusion Criteria:

  • None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01853904


Locations
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United States, Oklahoma
OUHSC
Oklahoma City, Oklahoma, United States, 73104
Sponsors and Collaborators
University of Oklahoma
Investigators
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Principal Investigator: Brent Brown, MD OUHSC
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Responsible Party: University of Oklahoma
ClinicalTrials.gov Identifier: NCT01853904    
Other Study ID Numbers: 2296
First Posted: May 15, 2013    Key Record Dates
Last Update Posted: January 7, 2014
Last Verified: January 2014
Keywords provided by University of Oklahoma:
Bronchoscopy
BAL
Suction