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Sleep Apnea and Visual Perceptual Skill Learning

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ClinicalTrials.gov Identifier: NCT01852929
Recruitment Status : Completed
First Posted : May 14, 2013
Last Update Posted : May 14, 2013
Sponsor:
Information provided by (Responsible Party):
Heidi Roth, MD, University of North Carolina, Chapel Hill

Brief Summary:
The purpose of this study is to determine whether obstructive sleep apnea affects sleep dependent memory and learning. Subjects with apnea will be given a test of perceptual skill learning (the Visual Discrimination Task (VDT)) that has previously been shown to depend on sleep. Subjects will be tested on this task before and after sleep. The difference in performance after sleep compared to before sleep provides a measure of sleep dependent learning. Participants will be tested on one night when they have less apnea because they are using continuous positive airway pressure (CPAP) as prescribed by their physician, which is well known to reduce apnea; and on another night when they are in their native state and have a greater degree of apnea. Memory performance will be compared between the two nights to determine how apnea affects sleep dependent memory.

Condition or disease Intervention/treatment Phase
Apnea Other: Subject using usual positive airway pressure therapy while sleeping for one night Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Official Title: The Effect of Sleep Apnea on Sleep Dependent Learning Using the Visual Discrimination Task.
Study Start Date : November 2009
Actual Primary Completion Date : April 2012
Actual Study Completion Date : May 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sleep Apnea

Arm Intervention/treatment
Apnea patients on and off PAP in order A
Subject using usual positive airway pressure therapy while sleeping for one night, then crossing over to not using usual apnea therapy while sleeping for another night.
Other: Subject using usual positive airway pressure therapy while sleeping for one night
Participants use their usual positive airway pressure therapy while sleeping overnight

Apnea patients on and off PAP in order B
Subject not using apnea therapy while sleeping for one night, then crossing over and subject using usual positive airway pressure therapy while sleeping for one night.
Other: Subject using usual positive airway pressure therapy while sleeping for one night
Participants use their usual positive airway pressure therapy while sleeping overnight




Primary Outcome Measures :
  1. VDT learning Change Score [ Time Frame: Change from baseline after 6-9 hours sleep ]
    Learning on the visual discrimination task (VDT) is measured by comparing performance on the perceptual task at a baseline session prior to sleep to that in a second session after sleep. Subjects are standardly tested in the hour prior to their typical bedtime, and re-tested after spontaneously awakening after a night of sleep. Sleep is known to consolidate learning on this task, such that more robust learning occurs after an interval of sleep compared to when the patient is awake over the same interval (Stickgold et al, J Cog Neurosci,2000; Stickgold et al., Nat Neurosci, 2000). Our aim is to determine if sleep dependent learning is disrupted by apnea, and preserved when apnea is eliminated.


Secondary Outcome Measures :
  1. Apnea Hypopnea Index (AHI) [ Time Frame: During minimum 6 hour sleep recording ]
    The AHI is a measure of the average number of respiratory events recorded per hour of sleep based on a record which includes a minimum of 6-hours of recorded sleep. Standard clinical categories for the severity of apnea are as follows: Mild = 5-10/ hour; Moderate = 10-15/ hour; Severe = >15/ hour. We will measure the Apnea Hypopnea Index on the night when participants are using their standard recommended PAP therapy and on the night when they are not using that therapy in order to be able to determine how the degree of apnea (AHI) correlates with the primary outcome measure.



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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Clinical diagnosis of sleep apnea
  • Use PAP therapy as prescribed by his/her physician for 3-4 weeks prior to enrollment
  • Right-handed

Exclusion Criteria:

  • Major neurological or psychiatric condition
  • Chronic pain condition
  • Learning disabilities
  • Serious brain or head injury (e.g. seizure, stroke, head trauma)
  • Major surgery or general anesthesia in the past year
  • Pregnant or nursing
  • Problems with eyes or vision (besides corrected-to-normal with glasses or contacts)
  • Past diagnosis of infection that can affect the brain (e.g. meningitis, HIV/AIDS)
  • Medications that affect sleep (antidepressants, muscle relaxants, sleep aids, beta-blockers, stimulants, or corticosteroids)
  • Recreational drug use, including marijuana
  • Night-shift work
  • Cancer or cancer treatment in the last 2 years
  • Smoke more than 10 cigarettes per day
  • Consume more than 3 caffeinated foods or beverages per day

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01852929


Locations
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United States, North Carolina
UNC Hospitals Sleep Disorders Center
Chapel Hill, North Carolina, United States, 27514
Sponsors and Collaborators
Heidi Roth, MD
Investigators
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Principal Investigator: Heidi Roth, MD University of North Carolina, Chapel Hill
Publications:
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Responsible Party: Heidi Roth, MD, Associate Professor of Neurology, University of North Carolina, Chapel Hill
ClinicalTrials.gov Identifier: NCT01852929    
Other Study ID Numbers: 09-1944
First Posted: May 14, 2013    Key Record Dates
Last Update Posted: May 14, 2013
Last Verified: May 2013
Keywords provided by Heidi Roth, MD, University of North Carolina, Chapel Hill:
Memory
Additional relevant MeSH terms:
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Apnea
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms