Melanocortin 4 Receptor Mutations and Obesity-associated Diseases (Mc4Obes)
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|ClinicalTrials.gov Identifier: NCT01849705|
Recruitment Status : Completed
First Posted : May 8, 2013
Last Update Posted : May 8, 2013
Mutations in the melanocortin 4 receptor (MC4R) are the most common form of monogenic obesity, and can explain 2-6% of severe obesity.
Studies have shown that mutations in MC4R are associated with increased fat mass, height-for-age, appetite and insulin resistance among children. In adults, mutations in MC4R are less penetrant for these phenotypes but it has been observed that individuals with MC4R mutations have a smaller than expected blood pressure for their degree of obesity.
The purpose of this study is to explore the association between functional MC4R mutations and obesity, insulin resistance and blood pressure.
|Condition or disease||Intervention/treatment|
|Obesity||Other: No intervention|
|Study Type :||Observational|
|Actual Enrollment :||226 participants|
|Official Title:||Mutations in the Melanocortin 4 Receptor and Obesity-associated Diseases|
|Study Start Date :||October 2012|
|Actual Primary Completion Date :||February 2013|
|Actual Study Completion Date :||February 2013|
Other: No intervention
- Blood pressure [ Time Frame: Baseline ]Systolic and diastolic blood pressure
- Obesity [ Time Frame: Baseline ]Obesity measured as BMI
- Blood glucose [ Time Frame: Baseline ]Blood glucose measured at baseline
- MC4R mutations [ Time Frame: Baseline ]MC4R mutations detected by sequencing of the coding region of the MC4R gene
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01849705
|Department of Nutrition, Exercise and Sports, University of Copenhagen|
|Frederiksberg, Frederiksberg C, Denmark, 1958|
|Study Director:||Arne Astrup, MD, Dr. Med||Department of Human Nutrition, University of Copenhagen|
|Principal Investigator:||Lesli H Larsen, PhD||Department of Human Nutrition, University of Copenhagen|