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Genetic Variability in Taste Perception

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ClinicalTrials.gov Identifier: NCT01841710
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : March 16, 2016
Sponsor:
Collaborators:
Children's Hospital of Philadelphia
University of Pennsylvania
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Julie A. Mennella, Monell Chemical Senses Center

Brief Summary:
This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

Condition or disease
Healthy

Detailed Description:
This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

Study Type : Observational
Actual Enrollment : 90 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Genetic Variability in Taste Perception
Study Start Date : December 2012
Actual Primary Completion Date : December 2015
Actual Study Completion Date : December 2015

Resource links provided by the National Library of Medicine


Group/Cohort
Women



Primary Outcome Measures :
  1. Psychophysical data for taste solutions [ Time Frame: 1-2 hours ]
    Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds.


Secondary Outcome Measures :
  1. Maternal practices and perceptions of medication use [ Time Frame: 1-2 hours ]
    Secondary outcome variables include questions related to maternal practices and perceptions of medication use and compliance of their children.


Biospecimen Retention:   Samples With DNA
Saliva


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
One hundred women who were previously enrolled in the study entitled "Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations," Protocol #809789; will be recruited for the current study
Criteria

Inclusion Criteria:

  • Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)

Exclusion Criteria:

  • Women who are pregnant
  • Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01841710


Locations
United States, Pennsylvania
Monell Chemical Senses Center
Philadelphia, Pennsylvania, United States, 19104
Sponsors and Collaborators
Monell Chemical Senses Center
Children's Hospital of Philadelphia
University of Pennsylvania
National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
Principal Investigator: Julie A. Mennella, PhD Monell Chemical Senses Center
Principal Investigator: Elizabeth Lowenthal, MD MSCE University of Pennsylvania

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Julie A. Mennella, Member, Monell Chemical Senses Center
ClinicalTrials.gov Identifier: NCT01841710     History of Changes
Other Study ID Numbers: 816980
R01DC011287 ( U.S. NIH Grant/Contract )
First Posted: April 26, 2013    Key Record Dates
Last Update Posted: March 16, 2016
Last Verified: March 2016

Keywords provided by Julie A. Mennella, Monell Chemical Senses Center:
Bitter Taste
Pediatric Medications