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Association of Carotid Arterial Circumferential Strain With Left Ventricular Function and Hemodynamic Compromise During Off-pump Coronary Artery Bypass Surgery

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ClinicalTrials.gov Identifier: NCT01840969
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : April 26, 2013
Sponsor:
Information provided by (Responsible Party):
Yonsei University

Brief Summary:
This study is aimed to evaluate the association of common carotid artery circumferential strain with the echocardiographic parameters of left ventricular function and the degree of actual hemodynamic deterioration in patients undergoing multi-vessel off-pump coronary artery bypass with preserved left ventricular ejection fraction.

Condition or disease
Three Vessel Coronary Artery Disease

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Study Type : Observational
Actual Enrollment : 96 participants
Observational Model: Case-Only
Time Perspective: Prospective
Study Start Date : September 2011
Actual Primary Completion Date : February 2013
Actual Study Completion Date : February 2013

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Group/Cohort
CAOD group
Single arm study group



Primary Outcome Measures :
  1. TTE parameters [ Time Frame: 1 day before the surgery ]
    TTE parameters: left ventricular ejection fraction, left atrial volume index, left ventricular mass, Sm, Em, E/Em


Secondary Outcome Measures :
  1. change of intraoperative hemodynamic variables [ Time Frame: from after induction of anesthesia, left circumflex artery grafting, and to sternum closure ]
    TTE parameters: left ventricular ejection fraction, left atrial volume index, left ventricular mass, Sm, Em, E/Em Carotid circumferential strain : Storage of transverse image of the right CCA at approximately 1cm proximal to the bifurcation, manual trace of luminal-intimal border and automatic tracking by frame-to-frame movement of ultrasound reflections (speckles) Hemodynamic variables: cardiac index and mixed venous oxygen saturation obtained from the pulmonary artery catheter and cardiac output monitoring devices



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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients scheduled for elective multivessel off-pump coronary artery bypass surgery
Criteria

Inclusion Criteria:

  1. three vessel coronary artery disease
  2. sinus rhythm

Exclusion Criteria:

  1. New York Heart Association functional class ≥3
  2. known pulmonary hypertension
  3. known valvular heart disease
  4. serum creatinine ≥2.0 mg/dL
  5. myocardial infarction within 1 week before the surgery
  6. history of cerebral or peripheral arterial occlusive disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01840969


Locations
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Korea, Republic of
Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University

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Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT01840969     History of Changes
Other Study ID Numbers: 4-2011-0467
First Posted: April 26, 2013    Key Record Dates
Last Update Posted: April 26, 2013
Last Verified: April 2013
Keywords provided by Yonsei University:
off-pump coronary artery bypass surgery
common carotid artery
speckle tracking analysis
peak strain
Additional relevant MeSH terms:
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Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases