Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects
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|ClinicalTrials.gov Identifier: NCT01840865|
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : March 16, 2016
|Condition or disease||Intervention/treatment||Phase|
|Healthy Subjects||Device: brain stimulation Device: no stimulation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Daytime Slow Wave Sleep in Younger, Healthy Subjects|
|Study Start Date :||October 2013|
|Actual Primary Completion Date :||January 2015|
|Actual Study Completion Date :||January 2015|
Experimental: SHAM stimulation
SHAM stimulation during periods of Slow Wave Sleep
Device: no stimulation
Experimental: 0,75 Hz stimulation
slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep
Device: brain stimulation
oscillating direct current brain stimulation
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ]Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
- Amount of Slow wave Sleep [ Time Frame: 4 weeks ]1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- 2. sleep spindles [ Time Frame: 4 weeks ]2. Spindle activity during sleep indicated via several spindle parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- 3. EEG-correlates [ Time Frame: 4 weeks ]3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- 4. further memory systems [ Time Frame: 4 weeks ]4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01840865
|Charite CCM Neurologie Berlin|
|Berlin, Germany, 10117|
|Principal Investigator:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|