Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
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|ClinicalTrials.gov Identifier: NCT01840839|
Recruitment Status : Completed
First Posted : April 26, 2013
Last Update Posted : January 30, 2018
|Condition or disease||Intervention/treatment||Phase|
|Older Adults (50-90 Years)||Device: brain stimulation Device: Sham Stimulation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Slow Wave Sleep in Older Adults|
|Study Start Date :||October 2013|
|Actual Primary Completion Date :||May 2015|
|Actual Study Completion Date :||August 2015|
Experimental: 0,75 Hz stimulation
transcranial slow oscilliating stimulation (tSOS)during periods of SWS
Device: brain stimulation
Other Name: oscillating direct current brain stimulation
Sham Comparator: no stimulation
Sham stimulation during periods of SWS
Device: Sham Stimulation
Other Name: no stimulation
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [ Time Frame: 4 weeks ]Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
- 1. Amount of Slow wave Sleep [ Time Frame: 4 weeks ]1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- 2. sleep spindels [ Time Frame: 4 weeks ]2.Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- 3. EEG-correlates [ Time Frame: 4 weeks ]3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- 4. further memory systems [ Time Frame: 4 weeks ]4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01840839
|Charite CCM Neurologie Berlin|
|Berlin, Germany, 10117|
|Study Chair:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|
|Principal Investigator:||Agnes Flöel, Professor||Charite Universitätsmedizin Berlin - Neurologie|