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Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments (CameraCue)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01840111
Recruitment Status : Completed
First Posted : April 25, 2013
Last Update Posted : January 31, 2017
Information provided by (Responsible Party):
Duke University

Brief Summary:

The overarching goals of this proposal are to 1) identify the network of brain regions specifically activated by personal smoking environment cues and 2) to evaluate the effects of exposure to these cues on smoke self-administration and subjective reactivity. The results of this study will inform the development of novel and more efficacious cue-exposures therapies targeted at helping smokers quit smoking and will provide novel mechanism information regarding the influence of environmental context on drug taking.

The investigator hypothesizes that cue-exposure treatments (CETs), in which drug use is prevented during exposure to drug cues (e.g. lit cigarette) have been of limited efficacy in part because they have not included cues representative of the contexts in which drug use occurs. By demonstrating that context cues have a differential and robust influence on brain and behavioral responses, we will have provided a substantial basis for including such stimuli in the context of treatment. At the same time, we will have identified novel mechanisms by which such stimuli promote continued drug use and relapse.

Condition or disease Intervention/treatment Phase
Smoking Healthy Behavioral: Quit Smoking 6 hours Behavioral: Quit Smoking 24 hours Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 67 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments
Study Start Date : December 2012
Actual Primary Completion Date : July 2014
Actual Study Completion Date : July 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Smoking

Intervention Details:
  • Behavioral: Quit Smoking 6 hours
    participants will quit smoking 6 hours prior to the cue-exposure sessions
  • Behavioral: Quit Smoking 24 hours
    participants will quit smoking 24 hours prior to the fMRI scan

Primary Outcome Measures :
  1. Signal Change in Functional Magnetic Resonance Imaging (fMRI) BOLD Signal between Personal Environment Pictures Relative to Standard Environment Pictures [ Time Frame: following 24 hours of smoking abstinence ]
    During fMRI scanning participants will view pictures of personal and standard smoking and non-smoking environments; and also pictures of smoking-related and non-smoking related objects

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • generally healthy
  • between the ages of 18 and 55
  • smoking an average of 5 cigarettes per day for at least one year
  • breath CO (carbon monoxide) level > 8 ppm (if ≤ 8 ppm, then NicAlert Strip > 2)
  • no interest in quitting smoking for the duration of time required for the experiment
  • right-handed as measured by a three-item scale used in our laboratory
  • ability to identify 4 personal smoking and 4 personal non-smoking places

Exclusion Criteria:

  • inability to attend all required experimental sessions
  • significant health problems
  • use of psychoactive medications
  • use of smokeless tobacco
  • current alcohol or drug abuse
  • use of illegal drugs as measured by urine drug screen
  • current use of nicotine replacement therapy or other smoking cessation treatment
  • presence of conditions that would make MRI unsafe (e.g., pacemaker)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01840111

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United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27705
Sponsors and Collaborators
Duke University
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Principal Investigator: Joseph McClernon, Ph.D Duke University

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Duke University Identifier: NCT01840111     History of Changes
Other Study ID Numbers: Pro00033975
First Posted: April 25, 2013    Key Record Dates
Last Update Posted: January 31, 2017
Last Verified: January 2017
Keywords provided by Duke University:
smoking environment