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Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01837056
Recruitment Status : Completed
First Posted : April 22, 2013
Last Update Posted : April 22, 2013
Sponsor:
Information provided by (Responsible Party):
Lim, Su Jin, Nune Eye Hospital, Seoul, Korea

Brief Summary:

Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis

  • serum antibody to T. gondii and T. canis
  • PCR with peripheral blood for T. gondii and T. canis
  • PCR with aqueous humor for T. gondii and T. canis
  • Clinical manifestation of patient with uveitis

Condition or disease
Uveitis

Detailed Description:

Consecutive patients with uveitis are enrolled in Nune Eye Hospital.

Serum ELISA

  • IgM,IgG antibody to Toxoplasma gondii
  • IgG antibody to Toxocara canis

PCR

  • PCR with serum and aqueous humor to Toxoplasma gondii
  • PCR with serum and aqueous humor to Toxocara canis Clinical characteristics
  • visual acuity
  • intraocular pressure (IOP)
  • location and degree of inflammation
  • other fundus findings were recorded

questionnaire

  • environment, occupation
  • pet ownership, exposure to animal
  • history of eating raw liver of animal, raw beef or any other raw flesh of animal.

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Study Type : Observational [Patient Registry]
Actual Enrollment : 98 participants
Observational Model: Case-Only
Time Perspective: Prospective
Target Follow-Up Duration: 14 Days
Official Title: Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis
Study Start Date : January 2011
Actual Primary Completion Date : February 2012
Actual Study Completion Date : February 2012

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis [ Time Frame: at baseline ]
    proportion of patients with seropositive for Toxoplasma gondii and Toxocara canis among patients


Secondary Outcome Measures :
  1. Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis [ Time Frame: at baseline ]
    Proportion of patient with positive PCR to Toxoplasma gondii and Toxocara canis


Other Outcome Measures:
  1. location of inflammation and fundus finding [ Time Frame: at baseline ]

    location of inflammation

    • anterior or posterior or panuveitis

    fundus finding

    • granuloma in macular or periphery retina
    • pigmentation

  2. Demographic characteristics [ Time Frame: at baseline ]
    • Gender
    • Residence
    • Pet ownership
    • Habit of eating uncooked meat



Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patient with uveitis
Criteria

Inclusion Criteria:

  • patients with uveitis

Exclusion Criteria:

  • Patients with history of major ophthalmic surgery within 6 months
  • antiviral, antifungal or antiparasitic therapy within 6 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01837056


Sponsors and Collaborators
National Institute of Health, Korea
Investigators
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Principal Investigator: Su Jin Lim, MD Nune Eye Hospital

Additional Information:

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Responsible Party: Lim, Su Jin, The retina staff, Nune Eye Hospital, Seoul, Korea
ClinicalTrials.gov Identifier: NCT01837056    
Other Study ID Numbers: Nuneuveitis
First Posted: April 22, 2013    Key Record Dates
Last Update Posted: April 22, 2013
Last Verified: April 2013
Keywords provided by Lim, Su Jin, Nune Eye Hospital, Seoul, Korea:
Toxoplasma gondii
Toxocara canis
Additional relevant MeSH terms:
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Uveitis
Uveal Diseases
Eye Diseases