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The Etiology and Progression of Brain Tumors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01811524
Recruitment Status : Completed
First Posted : March 14, 2013
Last Update Posted : March 19, 2013
Tampere University
Information provided by (Responsible Party):
Tampere University Hospital

Brief Summary:
The main goal of the study is to present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for different kinds of brain tumors. The investigators study the regulation of neoplastic cell growth by oncogenes, tumor-suppressor and other cancer related genes using modern molecular genetic methods, such as chromogenic-in-situ hybridization, comparative genomic hybridization (CGH), array-CGH, cDNA microarray etc. In these studies the investigators utilize disease-specific tissue microarrays (TMA) which the investigators have constructed since 1999. Until now up to 3000 different brain tumours have been sampled to our TMA:s. These permit high-volume simultaneous analysis of molecular targets at the DNA, mRNA and protein levels. Research group has also focused its interest on the neoplastic development of gliomas, particularly on their hereditary and environmental factors.

Condition or disease
Brain Tumor Glioma Meningioma

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Study Type : Observational
Actual Enrollment : 2000 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Etiology and Progression of Brain Tumors - Molecular Genetic Changes and Heredity
Study Start Date : September 1983
Actual Primary Completion Date : December 2009
Actual Study Completion Date : March 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Brain Tumors

Glioma and meningioma patientsl
Glioma and meningioma patients of Tampere University Hospital during the study period

Primary Outcome Measures :
  1. The prognostic value of new biomarkers in brain tumors [ Time Frame: September 1983 - December 2009 ]

Secondary Outcome Measures :
  1. Heredity of brain tumors [ Time Frame: September 1983 - December 2000 ]

Biospecimen Retention:   Samples With DNA
Paraffin-embedded and frozen brain tumor tissue

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Month to 85 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Glioma and meningioma patients

Inclusion Criteria: all glioma and meningioma patients 1983 - 2009

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01811524

Sponsors and Collaborators
Tampere University Hospital
Tampere University
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Principal Investigator: Hannu K Haapasalo, MD Fimlab Laboratories, Tampere University Hospital, Tampere, Finland
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Responsible Party: Tampere University Hospital Identifier: NCT01811524    
Other Study ID Numbers: R07042
First Posted: March 14, 2013    Key Record Dates
Last Update Posted: March 19, 2013
Last Verified: March 2013
Keywords provided by Tampere University Hospital:
Brain tumor
Additional relevant MeSH terms:
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Brain Neoplasms
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neoplasms, Vascular Tissue
Meningeal Neoplasms