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Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01811199
Recruitment Status : Unknown
Verified March 2013 by A.Ozdemir Aktan, Marmara University.
Recruitment status was:  Active, not recruiting
First Posted : March 14, 2013
Last Update Posted : March 14, 2013
Information provided by (Responsible Party):
A.Ozdemir Aktan, Marmara University

Brief Summary:
Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.

Condition or disease
Thyroid Cancer Breast Cancer

Detailed Description:
This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels
Study Start Date : February 2011
Estimated Primary Completion Date : April 2013
Estimated Study Completion Date : May 2013

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Number of participants will be evaluated to show effect of dexamethasone in reducing postoperative emesis [ Time Frame: up to 3 days ]
    participants will be followed for the duration of hospital stay, till they are discharged in avarage 3 days for postoperative emesis.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing thyroidectomy and mastectomy

Inclusion Criteria:

  • breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent

Exclusion Criteria:

  • ones who did not sign the consent form NSAID or steroid users

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01811199

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Marmara University School of Medicine
Istanbul, Turkey
Sponsors and Collaborators
Marmara University
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Principal Investigator: A.Ozdemir Aktan, MD,prof Marmara University
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Responsible Party: A.Ozdemir Aktan, professor of surgery, Marmara University Identifier: NCT01811199    
Other Study ID Numbers: 09.2011.0024
First Posted: March 14, 2013    Key Record Dates
Last Update Posted: March 14, 2013
Last Verified: March 2013
Keywords provided by A.Ozdemir Aktan, Marmara University:
Thyroid cancer
Breast cancer
Additional relevant MeSH terms:
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Thyroid Neoplasms
Postoperative Nausea and Vomiting
Neoplasms by Site
Thyroid Diseases
Endocrine System Diseases
Endocrine Gland Neoplasms
Head and Neck Neoplasms
Signs and Symptoms, Digestive
Postoperative Complications
Pathologic Processes