Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels
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ClinicalTrials.gov Identifier: NCT01811199
Recruitment Status : Unknown
Verified March 2013 by A.Ozdemir Aktan, Marmara University. Recruitment status was: Active, not recruiting
Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.
Condition or disease
Thyroid CancerBreast Cancer
This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.
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Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients undergoing thyroidectomy and mastectomy
breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent
ones who did not sign the consent form NSAID or steroid users
Keywords provided by A.Ozdemir Aktan, Marmara University:
Additional relevant MeSH terms:
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Postoperative Nausea and Vomiting
Neoplasms by Site
Endocrine System Diseases
Endocrine Gland Neoplasms
Head and Neck Neoplasms
Signs and Symptoms, Digestive
Signs and Symptoms