Neural Functioning of Feeding Centers in Obese Youth
|ClinicalTrials.gov Identifier: NCT01808846|
Recruitment Status : Completed
First Posted : March 11, 2013
Last Update Posted : April 27, 2017
To explore whether obese adolescents with insulin resistance and relative low leptin levels exhibit functional alterations of the neuronal circuits involved in the regulation of energy metabolism and food seeking behaviors.
We here propose to test the hypothesis that the reward circuitry is dysregulated in obese adolescents and is related to the degree of insulin resistance and hyperinsulinemia.
|Condition or disease|
|Obesity Insulin Resistance|
|Study Type :||Observational|
|Actual Enrollment :||51 participants|
|Official Title:||Neural Functioning of Feeding Centers in Obese Youth|
|Actual Study Start Date :||July 2010|
|Actual Primary Completion Date :||February 2017|
|Actual Study Completion Date :||February 2017|
Kids aged 12-17 with body mass index less than 25% and normal glucose tolerance test results
Obese Insulin Sensitive
Obese Insulin Sensitive Adolescents aged 12-17 with BMI>95th% and whole body insulin sensitivity index > 3.
Obese Insulin Resistant Adolscent
Obese Insulin Resistant Adolescents 12-17 with BMI> 95th% and WBISI<1.2.
- measure of cerebral blood flow response to glucose ingestion [ Time Frame: Baseline and 2 year follow up ]fmri on 3T to measure blood flow response after ingestion of glucose drink
- measure of cerebral blood flow response to fructose ingestion [ Time Frame: Baseline and 2 year follow up ]fmri on 3T to measure blood flow response after ingestion of fructose drink
- measure of BOLD signal brain reactivity to food cues [ Time Frame: Baseline and 2 year follow up ]fmri on 3T to measure blood flow response to visually presented food cues
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01808846
|United States, Connecticut|
|New Haven, Connecticut, United States, 06510|
|Principal Investigator:||Sonia Caprio, M.D.||Yale University|