Hyperoxic Oxidative Stress During Abdominal Surgery
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|ClinicalTrials.gov Identifier: NCT01793454|
Recruitment Status : Completed
First Posted : February 15, 2013
Last Update Posted : April 9, 2015
|Condition or disease||Intervention/treatment||Phase|
|Response to Hyperoxia||Other: Fraction of inspired oxygen 40% Other: Fraction of inspired oxygen 80%||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Comparing the Effect of Hyperoxic and Conventional Fraction of Inspired Oxygen on Oxidative Stress During Abdominal Surgery.|
|Study Start Date :||February 2013|
|Actual Primary Completion Date :||May 2013|
|Actual Study Completion Date :||May 2013|
Active Comparator: 40% oxygen
Patients in this group will be ventilated with fraction of inspired oxygen 40% during the surgery.
Other: Fraction of inspired oxygen 40%
Active Comparator: 80% oxygen
Patients in this group will be ventilated with a fraction of inspired oxygen 80% during the surgery.
Other: Fraction of inspired oxygen 80%
- oxidant and antioxidant response [ Time Frame: 4 hours ]As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated
- Hemodynamics [ Time Frame: 4 hours ]The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01793454
|Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department|
|Istanbul, Fatih, Turkey, 34400|
|Study Director:||Yalim Dikmen, Prof.||Cerrahpasa Medical Faculty Chairman of Intensive Care Department|