Capillary Lactate and Transfusion Needs
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|ClinicalTrials.gov Identifier: NCT01793428|
Recruitment Status : Completed
First Posted : February 15, 2013
Last Update Posted : April 3, 2015
13% of injured normotensive patients arriving in emergency unit need mass blood-transfusion of six or more units of packed Red Blood Cells. It is currently difficult to predict the need for such a mass blood-transfusion. Indeed hemoglobin point of care testing (hemocue) and blood pressure can be normal during the first hours despite intensive bleeding.
It's well known that blood or arterial lactate measures correlate with trauma severity but these measures are not available in a pre-hospital setting. The investigators want to test whether capillary lactate measures also correlate with trauma severity and can therefore predicts earlier transfusion needs.
|Condition or disease||Intervention/treatment|
|Trauma||Other: Capillary lactate level|
|Study Type :||Observational|
|Actual Enrollment :||120 participants|
|Official Title:||Predictive Abilities for Transfusion Needs of Capillary Lactate Measure in Emergency for Injured Normotensive Patients|
|Study Start Date :||August 2011|
|Actual Primary Completion Date :||February 2013|
|Injured patient admitted in vital emergency unit||
Other: Capillary lactate level
Use of capillary sample to determine lactate level upon arrival at vital emergency unit and at 2 hours
- Transfusion of 6 or more units of packed Red Blood Cells (RBC) [ Time Frame: 48 hours ]
- arterial lactate measures [ Time Frame: upon arrival at the vital emergency unit ]
- injury scores (ISS,SOFA) [ Time Frame: 24h ]
- transfusion of 4 units of packed RBC [ Time Frame: 48 hours ]
- blood lactate measure [ Time Frame: upon arrival at vital emergency unit ]
- Intensity of medical care [ Time Frame: upon arrival at vital emergency unit ]Body scan Central venous catheterisation arterial catheterisation
- Bleeding Predictive Score [ Time Frame: upon arrival at vital emergency unit ]3 questions are asked to the doctor in emergency room. Could patient be admitted directly at the CT scan ? Do you think that the patient need transfusion ? If Yes : and how many units ? Do you think that the patient will be hospitalized in an intensive care unit after the emergency room?
- Mortality [ Time Frame: 28 days ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01793428
|Grenoble University Hospital|
|La Tronche, Isere, France, 38700|
|Principal Investigator:||Marc Vinclair, MD||University Hospital, Grenoble|