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Registry and Prevalence of Gene Mutation in Korean Patients With Familial Hypertrophic Cardiomyopathy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01792960
Recruitment Status : Completed
First Posted : February 15, 2013
Last Update Posted : February 19, 2014
Information provided by (Responsible Party):
Yonsei University

Brief Summary:
Set the Korean Familial Hypertrophic Cardiomyopathy (KFHC) registry to study the prevalence of gene mutations in Korean patients with familial hypertrophic cardiomyopathy

Condition or disease
Familial Hypertrophic Cardiomyopathy

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Study Type : Observational [Patient Registry]
Actual Enrollment : 99 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 2 Years
Study Start Date : February 2013
Actual Primary Completion Date : August 2013
Actual Study Completion Date : August 2013

familial hypertrophic cardiomyopathy
familial hypertrophic cardiomyopathy patients and their relatives

Primary Outcome Measures :
  1. 1) DNA analysis [ Time Frame: 1 year ]
    1) Identify susceptible genes for familial hypertrophic cardiomyopathy in Korean

Secondary Outcome Measures :
  1. 2) Prognosis of familial hypertrophic cariomyopathy [ Time Frame: 1 year ]
    2) all-cause mortality, hospitalization for heart failure progression, stroke, heart transplantation

Biospecimen Retention:   Samples With DNA
serum, whole blood, DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   13 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
familial hypertrophic cardiomyopathy patients and their relatives

Inclusion Criteria:

  1. left ventricular maximal wall thickness ≥ 15mm on echocardiography
  2. hypertrophic cardiomyopathy patients' relatives

Exclusion Criteria:

  1. other cardiomyopathy or systemic disease (e.g. fabry disease, danon disease, glycogen storage disease)
  2. who deny the study entrance, especially in patients' relatives

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01792960

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Korea, Republic of
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University

Additional Information:

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Responsible Party: Yonsei University Identifier: NCT01792960    
Other Study ID Numbers: 4-2012-0869
First Posted: February 15, 2013    Key Record Dates
Last Update Posted: February 19, 2014
Last Verified: February 2014
Additional relevant MeSH terms:
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Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic, Familial
Heart Diseases
Cardiovascular Diseases
Pathological Conditions, Anatomical
Aortic Stenosis, Subvalvular
Aortic Valve Stenosis
Heart Valve Diseases
Genetic Diseases, Inborn