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Stress Reactivity of Physical Stressor on Depression

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ClinicalTrials.gov Identifier: NCT01791023
Recruitment Status : Completed
First Posted : February 13, 2013
Last Update Posted : February 13, 2013
Sponsor:
Information provided by (Responsible Party):
Helena Sales de Moraes, Universidade Federal do Rio de Janeiro

Brief Summary:
Depressive elderly individuals have showed higher basal level of cortisol and lower level of dehydroepiandrosterone (DHEA). Moreover, changes on these hormone levels have also observed in reactivity of an acute stress, such as physical exercise. On the other hand, physical training can modulate the release of these hormones. Therefore, depressive elderly individuals physically actives might show attenuated reactivity of an acute physical stressor compared to sedentary elderly individuals. The aim of these study is to compare the effect of an acute physical stressor on cortisol levels in depressive and healthy individuals, physically actives and sedentaries. Additionally, the sulfated form of DHEA (DHEAS) serves as a reservoir for DHEA, because of that it is expected that DHEAS levels might reduce after the acute physical exercise.

Condition or disease Intervention/treatment Phase
Depression Other: Physical exercise Not Applicable

Detailed Description:
Depressive and healthy individuals were submitted to one session of 30 minutes of physical exercise of moderate intensity. Before and soon after the exercise it was collected saliva - to analyse cortisol and DHEAS hormones - and some psychological and physical aspects were also collected, such as anamneses, scales of anxiety, temperaments, mood, stress and quality of life. Moreover, during exercise heart rate and mood scale were assessed. To evaluate the reactivity and recovery of physical stressor (physical exercise) saliva tubes and psychological scales were collected 30 minutes and 45 minutes after the end of exercise.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 80 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effect of Acute Exercise on Reactivity and Recovery of Cortisol and DHEAS Levels in Depressive and Healthy Older Adults.
Study Start Date : March 2011
Actual Primary Completion Date : August 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Physical exercise
Physical exercise
Other: Physical exercise
30 minutes of aerobic exercise on treadmill with moderate intensity.




Primary Outcome Measures :
  1. Changes from baseline in cortisol and DHEAS levels to after an acute session of exercise [ Time Frame: From before and to after one session of 30 minutes of exercise. ]


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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age above of 60 years old
  • Clinical diagnostic of depression

Exclusion Criteria:

  • Hormonal replacement
  • Physical disease
  • Fasting

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01791023


Locations
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Brazil
Deolindo Couto Neurology Institute
Rio de Janeiro, RJ, Brazil
Sponsors and Collaborators
Universidade Federal do Rio de Janeiro
Investigators
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Principal Investigator: Helena S Moraes, Ms Universidade Federal do Rio de Janeiro

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Responsible Party: Helena Sales de Moraes, Principal investigator, Universidade Federal do Rio de Janeiro
ClinicalTrials.gov Identifier: NCT01791023     History of Changes
Other Study ID Numbers: cortisolexercise01
First Posted: February 13, 2013    Key Record Dates
Last Update Posted: February 13, 2013
Last Verified: February 2013
Keywords provided by Helena Sales de Moraes, Universidade Federal do Rio de Janeiro:
Depression
Physical exercise
Stress
Additional relevant MeSH terms:
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Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders