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Trial record 28 of 1555 for:    Slovakia

Genetics and Mechanisms of Rheumatoid Arthritis (RASGENAS)

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ClinicalTrials.gov Identifier: NCT01788098
Recruitment Status : Completed
First Posted : February 11, 2013
Last Update Posted : February 11, 2013
Sponsor:
Information provided by (Responsible Party):
Stefan Zorad, Slovak Academy of Sciences

Brief Summary:
The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.

Condition or disease
Rheumatoid Arthritis Leukocytes, Mononuclear Genetic Association Studies

Study Type : Observational
Actual Enrollment : 790 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Rheumatoid Arthritis Susceptibility Genes in Austrian and Slovak Population
Study Start Date : October 2009
Actual Primary Completion Date : June 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine


Group/Cohort
Rheumatoid Arthritis
Patients with rheumatoid arthritis
Healthy controls
Healthy control subjects



Primary Outcome Measures :
  1. Genetic association [ Time Frame: 1 day ]
    Association of selected single nucleotide polymorphisms with rheumatoid arthritis.


Secondary Outcome Measures :
  1. Peripheral blood mononuclear cells reactivity [ Time Frame: 1 day ]
    Reactivity and functional changes of peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis in comparison to healthy controls.


Biospecimen Retention:   Samples With DNA
frozen immune cells frozen serum frozen DNA


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients with rheumatoid arthritis and healthy controls from Slovakia and Austria
Criteria

Inclusion Criteria:

  • rheumatoid arthritis or healthy

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01788098


Locations
Slovakia
Slovak Academy of Sciences, Center for Molecular Medicine
Bratislava, Slovakia, 83101
Sponsors and Collaborators
Slovak Academy of Sciences
Investigators
Study Chair: Richard Imrich Slovak Academy of Sciences, Center for Molecular Medicine

Responsible Party: Stefan Zorad, Head of Laboratory, Slovak Academy of Sciences
ClinicalTrials.gov Identifier: NCT01788098     History of Changes
Other Study ID Numbers: RASGENAS
ATMOS N00024 ( Other Grant/Funding Number: Cross Border Cooperation Slovakia - Austria 2007 - 2013 )
First Posted: February 11, 2013    Key Record Dates
Last Update Posted: February 11, 2013
Last Verified: February 2013

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases