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Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training

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ClinicalTrials.gov Identifier: NCT01784432
Recruitment Status : Completed
First Posted : February 5, 2013
Last Update Posted : February 5, 2013
Sponsor:
Collaborators:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Centro de Pequisas de Ótica e Fotônica
Faculty of Medicine of Ribeirão Preto (FMRP-USP)
Fundação Hemocentro de Ribeirão Preto
Information provided by (Responsible Party):
Cleber Ferraresi, Universidade Federal de Sao Carlos

Brief Summary:
Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, low-level laser therapy has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations on global gene expression of muscle tissue influenced by exercise associated to low-level laser therapy.

Condition or disease Intervention/treatment Phase
Healthy Device: Low-level laser therapy and training Other: Training Not Applicable

Detailed Description:
This study assessed muscle performance in isokinetic dynamometry and leg press device; global gene expression of muscle tissue by microarray analysis

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training
Study Start Date : January 2011
Actual Primary Completion Date : January 2012
Actual Study Completion Date : September 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Low-level laser therapy and training
Effects of low-level laser therapy on muscle performance during physical strength training and gene expression of muscle tissue.
Device: Low-level laser therapy and training
Other Names:
  • Laser
  • Laser therapy
  • Low-level laser therapy

Active Comparator: Training without low-level laser therapy
Effects of physical strength training without low-level laser therapy on muscle performance and gene expression of muscle tissue
Other: Training



Primary Outcome Measures :
  1. Global gene expression by microarray analysis [ Time Frame: 12 weeks ]

Secondary Outcome Measures :
  1. Muscle performance in leg press device [ Time Frame: 12 weeks ]
  2. Muscle performance in isokinetic dynamometer [ Time Frame: 12 weeks ]

Other Outcome Measures:
  1. Immunohistochemical analysis [ Time Frame: 12 weeks ]
    Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.



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Ages Eligible for Study:   18 Years to 28 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy males aged between 18 and 28 years;
  • body mass index (BMI) equal to or less than 26 kg/m2;
  • moderated pattern of physical activity

Exclusion Criteria:

  • previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
  • osseous or articular disorder in the lower limbs,
  • cardiovascular system disorders,
  • systemic disease, and
  • taking prescription medicines or using dietary supplements such as muscle mass builders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01784432


Locations
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Brazil
Federal University of São Carlos
São Carlos, São Paulo, Brazil, 13565-905
Sponsors and Collaborators
Universidade Federal de Sao Carlos
Fundação de Amparo à Pesquisa do Estado de São Paulo
Centro de Pequisas de Ótica e Fotônica
Faculty of Medicine of Ribeirão Preto (FMRP-USP)
Fundação Hemocentro de Ribeirão Preto
Investigators
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Principal Investigator: Cleber Ferraresi, MSc Universidade Federal de Sao Carlos
Study Director: Nivaldo A Parizotto, PhD Universidade Federal de Sao Carlos
Study Director: Vanderlei S Bagnato, PhD University of São Paulo