Efficacy and Safety of Mate Extracts on Decrement of Body and Abdominal Fat in Obese Subjects
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ClinicalTrials.gov Identifier: NCT01778257 |
Recruitment Status :
Completed
First Posted : January 29, 2013
Last Update Posted : January 29, 2013
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Condition or disease | Intervention/treatment | Phase |
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Obesity | Dietary Supplement: Mate extract Dietary Supplement: Placebo | Phase 2 |
The primary aim of the study was to investigate the effect of Mate extracts in Korean subjects on body fat and abdominal fat, double blind, placebo-controlled clinical trial.
Thirty obesity subjects with BMI ≥ 25 kg/㎡ and waist-hip ratio (WHR)≥ 0.90 for men and ≥ 0.85 for women were for 12 weeks.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 30 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Prevention |
Official Title: | Mate Extract Supplementation Reduces Body and Abdominal Fat in Obese Korean Subjects |
Study Start Date : | October 2011 |
Actual Primary Completion Date : | February 2012 |
Actual Study Completion Date : | March 2012 |

Arm | Intervention/treatment |
---|---|
Experimental: Mate extracts group
Mate extract(3150 mg/day)for 12 weeks
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Dietary Supplement: Mate extract
Mate is a South American herb that is traditionally prepared as a tea and used, among others, for weight reduction.
Other Name: Extracts of Ilex paraguariensis A. St.-Hil. |
Placebo Comparator: Placebo group
Placebo (3150 mg/day) for 12 weeks
|
Dietary Supplement: Placebo
Amount and calorie of placebo are same with Mate extracts. |
- Changes in body and abdominal fat [ Time Frame: body fat: baseline, 6 weeks and 12 weeks, abdominal fat of CT: baseline and 12 weeks ]
- Changes in anthropometric parameters(weight, BMI, waist and hip circumference) [ Time Frame: baseline, 6 weeks and 12 weeks ]
- Changes in blood lipid profile(total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, free fatty acid) [ Time Frame: baseline, 6 weeks and 12 weeks ]

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Ages Eligible for Study: | 19 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Volunteers aged 19 to 65 years
- 25 kg/m2 ≤ BMI ≥35 kg/m2
- Ability to give informed consent
Exclusion Criteria:
- Significant variation in weight (more 10%) in the past 3 month
- Cardiovascular disease, neurologic or psychiatric disease, renal, pulmonary and hepatic abnormalities
- History of disease that could interfere with the test products or impede their absorption, such as gastrointestinal disease (Crohn's disease) or gastrointestinal surgery (a caesum or enterocele surgery are included)
- Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the sutdy
- Allergic or hypersensitive to any of the ingredients in the test products
- Pregnancy or breast feeding
- Used antipsychosis drugs therapy within past 2 months
- History of alcohol or substance abuse (21 units/week over)
- Participation in any other clinical trials within past 3 months

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01778257
Principal Investigator: | Min-Gul Kim, MD | Chonbuk National University Hospital |
Responsible Party: | Min-Gul Kim, MD, Clinical Assistant Professor, Chonbuk National University Hospital |
ClinicalTrials.gov Identifier: | NCT01778257 |
Other Study ID Numbers: |
CUH_2011_GS_MATE |
First Posted: | January 29, 2013 Key Record Dates |
Last Update Posted: | January 29, 2013 |
Last Verified: | January 2013 |
Mate extracts Obesity abdominal fat |
Obesity Overnutrition Nutrition Disorders Overweight Body Weight |