Continued Access to PREVAIL (CAP2) - WATCHMAN Left Atrial Appendage (LAA) Closure Technology (CAP2)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01760291 |
Recruitment Status :
Completed
First Posted : January 4, 2013
Last Update Posted : April 24, 2020
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Atrial Fibrillation | Device: WATCHMAN LAA Closure Technology | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 578 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Continued Access to PREVAIL (CAP2)- WATCHMAN Left Atrial Appendage (LAA) Closure Technology |
Study Start Date : | September 2012 |
Actual Primary Completion Date : | April 2019 |
Actual Study Completion Date : | April 2019 |

Arm | Intervention/treatment |
---|---|
Experimental: WATCHMAN
WATCHMAN LAA Closure Technology
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Device: WATCHMAN LAA Closure Technology |
- Incidence of stroke leading to significant disability/death [ Time Frame: up to 5 years ]Stroke leading to significant disability/death

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria: A subject may be enrolled in the study if all of the following inclusion criteria are met:
- The subject is 18 years of age or older
- The subject has documented paroxysmal, persistent, or permanent non- valvular atrial fibrillation (i.e., the subject has not been diagnosed with rheumatic mitral valvular heart disease)
- The subject is eligible for long-term warfarin therapy
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The subject has a calculated CHADS2 score of 2 or greater; Subjects with a CHADS2 score of 1 may be included if any of the following apply (according to the ACC/AHA/ESC 2006 Guidelines for the Management of
Subjects with Atrial Fibrillation subjects requiring warfarin therapy):
- The subject is a female age 75 or older
- The subject has a baseline Left Ventricular Ejection Fraction (LVEF) > 30% and < 35%
- The subject is age 65-74 and has diabetes or coronary artery disease
- The subject is age 65 or greater and has documented congestive heart failure
- The subject or legal representative is able to understand and willing to provide written informed consent to participate in the trial
- The subject is able and willing to return for required follow-up visits and examinations
Exclusion Criteria:
Subjects will be excluded from the study if they meet any of the following criteria:
-
The subject requires long-term warfarin therapy (i.e., even if the device is implanted, the subjects would not be eligible to discontinue warfarin due to other medical conditions requiring chronic warfarin therapy). Additionally, a subject with any of the following is excluded:
- Thrombosis occurring at a young age (<40 years old)
- Idiopathic or recurrent venous thromboembolism
- Thrombosis at an unusual site (i.e., cerebral veins, hepatic veins,renal veins, inferior vena cava, mesenteric veins)
- Family history of venous thromboembolism or of inherited prothrombotic disorder
- Recurrence or extension of thrombosis while adequately anticoagulated
- The subject is contraindicated for warfarin therapy or cannot tolerate long-term warfarin therapy
- The subject is contraindicated or allergic to aspirin
- The subject is indicated for antiplatelet therapy other than aspirin (for example, a subject indicated for clopidogrel, prasugrel, ticlopidine or ticagrelor due to DES is excluded from enrollment during the dosing regimen). A subject completing a course of antiplatelet therapy may be enrolled after a 7 day washout period
- The subject had any interventional or surgical procedure within 30 days prior to enrollment or is planning to have an interventional or surgical procedure in the time between the WATCHMAN device implant and 45-day TEE (e.g., cardioversion, ablation, cataract surgery, dental surgery)
- The subject had a prior stroke or TIA within the 90 days prior to enrollment
- The subject has had an MI within 90 days prior to enrollment
- The subject has a history of atrial septal repair or has an ASD/PFO device
- The subject has an implanted mechanical valve prosthesis
- The subject suffers from New York Heart Association Class IV Congestive Heart Failure at the time of enrollment
- The subject has symptomatic carotid disease (defined as >50% stenosis with symptoms of ipsilateral transient or visual TIA evidenced by amaurosis fugax, ipsilateral hemispheric TIAs or ipsilateral stroke); if subject has a history of carotid stent or endarterectomy the subject is eligible if there is < 50% stenosis
- The subject's AF is defined by a single occurrence of AF
- The subject had a transient case of AF (i.e., secondary to CABG, interventional procedure, etc.)
- The subject's left atrial appendage is obliterated
- The subject has undergone heart transplantation
- The subject is currently treated with antibiotics for an active infection
- The subject has a resting heart rate > 110 bpm
- The subject has thrombocytopenia (defined as < 70,000 platelets/mm3) or anemia with hemoglobin concentration of < 10 g/dl (i.e., anemia as determined by the investigator which would require transfusion)
- The subject is actively enrolled in a concurrent clinical study of an investigational drug or investigational device (study specifics may be reviewed with the sponsor prior to enrollment to confirm a concurrent study will not interfere with the outcomes of this study)
- The subject participated in any of the following studies: PROTECT AF, CAP Registry, or PREVAIL. If the subject received a subject ID number for a prior WATCHMAN study, the subject may not be enrolled. PROTECT AF control subjects may be considered for participation if they have completed 5 year follow up
- The subject is pregnant or pregnancy is planned during the course of the investigation
- The subject has a life expectancy of less than two years
- The subject is unable to complete follow-up visits for the duration of the study
Echo Exclusion Criteria
A subject is excluded from the study if any of the following echocardiographic exclusion criteria (as assessed via TTE and TEE) are met:
- The subject has LVEF < 30%
- The subject has intracardiac thrombus or dense spontaneous echo contrast as visualized by TEE and determined by the echocardiographer within 2 days prior to implant
- The subject has an existing pericardial effusion > 2mm
- The subject has a high risk patent foramen ovale (PFO) with an atrial septal aneurysm excursion > 15mm or length > 15mm
- The subject has a high risk PFO with a large shunt defined as early, within 3 beats or substantial passage of bubbles
- The subject has significant mitral valve stenosis (i.e., MV <1.5 cm2)
- The subject has complex atheroma with mobile plaque of the descending aorta or aortic arch
- The subject has a cardiac tumor

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01760291
United States, Arizona | |
Arizona Heart Rhythm Research Center | |
Phoenix, Arizona, United States, 85006 | |
United States, Kentucky | |
Central Baptist Hospital | |
Lexington, Kentucky, United States, 40503 | |
United States, New York | |
Mount Sinai Medical Center | |
New York, New York, United States, 10029 |
Principal Investigator: | Saibal Kar, M.D. | Cedars-Sinai Medical Center | |
Principal Investigator: | Shephal Doshi, M.D. | Pacific Heart |
Responsible Party: | Boston Scientific Corporation |
ClinicalTrials.gov Identifier: | NCT01760291 |
Other Study ID Numbers: |
S2278 |
First Posted: | January 4, 2013 Key Record Dates |
Last Update Posted: | April 24, 2020 |
Last Verified: | April 2020 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Atrial Fibrillation Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes |