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The Effect and Mechanism of Hyaluronan on the Mucociliary Differentiation of Human Respiratory Epithelial Cells

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01754584
Recruitment Status : Unknown
Verified November 2012 by Far Eastern Memorial Hospital.
Recruitment status was:  Not yet recruiting
First Posted : December 21, 2012
Last Update Posted : December 21, 2012
Information provided by:
Far Eastern Memorial Hospital

Brief Summary:
The mucociliary system of nasal mucosa, which is composed of the ciliated respiratory epithelium, the mucous blanket, and the mucus-producing glands, is an important defense component of the respiratory system. Therefore, it is important to maintain intact inner respiratory mucociliary epithelium in reconstruction of large respiratory defect and in the development of tissue engineering trachea. Hyaluronan derivatives, which are biodegradable and non-immunogenic, have already proved to be effective as a scaffold for chondrocytes. However, the feasibility of use as a scaffold for respiratory epithelial cells remained unexplored. The aim of the study is to investigate the effect of hyaluronan including concentrations and molecular weight on the mucociliary differentiation of human respiratory epithelial cells (HREC). If hyaluronan is able to promote mucociliary differentiation of HREC, the investigators can synthesize hyaluronan derivatives serving as ideal biomaterials for respiratory tissue engineering and tissue-engineered trachea in the future.

Condition or disease
Respiratory System Defect

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Study Type : Observational
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Effect and Mechanism of Hyaluronan on the Mucociliary Differentiation of Human Respiratory Epithelial Cells
Study Start Date : January 2009

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population

Inclusion Criteria:

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Responsible Party: Far Eastern Memorial Hospital-IRB Identifier: NCT01754584    
Other Study ID Numbers: FEMH 97055
First Posted: December 21, 2012    Key Record Dates
Last Update Posted: December 21, 2012
Last Verified: November 2012
Keywords provided by Far Eastern Memorial Hospital:
hyaluronan including concentrations
molecular weight
mucociliary differentiation
human respiratory epithelial cells