Novel Imaging Approaches To Identify Unstable Coronary Plaques
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|ClinicalTrials.gov Identifier: NCT01749254|
Recruitment Status : Unknown
Verified December 2012 by University of Edinburgh.
Recruitment status was: Recruiting
First Posted : December 13, 2012
Last Update Posted : December 13, 2012
|Condition or disease|
|Coronary Artery Disease|
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||Novel Imaging Approaches To Identify Unstable Coronary Plaques|
|Study Start Date :||February 2012|
|Estimated Primary Completion Date :||February 2013|
Acute Coronary Syndrome
40 patients admitted with ACS (NSTEMI/STEMI) will be recruited undergo 18F NaF PET, 18F FDG and CTCA within 1 month of the event.
Stable angina cohort
40 patients with previously diagnosed coronary artery disease and listed to undergo elective coronary angiogram will be recruited. VH-IVUS will be attempted in all patients. Selected patients will undergo PET scan after stent implantation.
- Patients with ACS have focal 18F-NaF uptake and high tissue to background ratio(TBR) and standardised uptake values (SUV) in the culprit vessels. [ Time Frame: Within 1 month of index event ]Using PET/CT, the investigators will assess if there is presence of focal uptake at the areas of plaque ruptures in patients presenting with ACS. Standardised uptake values and Tissue to Background ratios of the culprit vessels with be compared with non-culprit lesions.
- What are the morphological characteristics of plaque with high 18F-NaF tissue to background ratio or standardised uptake value [ Time Frame: 1 month ]Using VH-IVUS, the investigators will look at the morphological characteristics of plaques that have higher SUVs and TBRs. Additional information about the plaque characteristics will be derived from CT coronary angiogram
- Is there a co-relation between the two PET/CT tracers(18FDG and 18F NaF) as measured as Tissue to background ratio or standardised uptake value. [ Time Frame: 1 month ]
- Is there a difference between the coronary and aortic TBR/SUVs in stable and unstable patients [ Time Frame: 1 month ]The investigators will look for differences in activity in stable angina and ACS patients using 18F-NaF and 18F-FDG
- Will patients with higher 18F-NaF uptake as measured by SUV/TBR will have higher levels of cardiac biomarkers such as hsCRP or Troponin [ Time Frame: 1 year ]Blood collected from volunteers in the study will be analysed for inflammatory biomarkers such as hsCRP and Troponin
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01749254
|Clinical Research Imaging Centre/ NHS LOTHIAN||Recruiting|
|Edinburgh, Midlothian, United Kingdom, EH16 4SB|
|Contact: DAVID NEWBY, MD PHD 0131 242 6515 firstname.lastname@example.org|
|Principal Investigator: Nikhil Joshi, MD|