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The Genetics Behind Vitamin D Status (VitDgen) (VitDgen)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01741233
Recruitment Status : Completed
First Posted : December 4, 2012
Last Update Posted : August 1, 2013
Sponsor:
Collaborator:
Bispebjerg Hospital
Information provided by (Responsible Party):
Lone Banke Rasmussen, Technical University of Denmark

Brief Summary:

The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.

The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.


Condition or disease Intervention/treatment Phase
Vitamin D Deficiency Genetic: VitDgen Not Applicable

Detailed Description:

In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .

Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 102 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Genetics Behind Vitamin D Status (VitDgen)
Study Start Date : November 2012
Actual Primary Completion Date : March 2013
Actual Study Completion Date : March 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vitamin D

Arm Intervention/treatment
Experimental: UV-B irraditation
VitDgen
Genetic: VitDgen



Primary Outcome Measures :
  1. serum 25-hydroxyvitamin D [ Time Frame: 10 days ]
    Measures the vitamin D status i serum at baseline and at the end of the project


Secondary Outcome Measures :
  1. Skintest [ Time Frame: 10 days ]
    Optimize scientific; measures pigmentation and redness of the skin. Are measured at baseline and at end of project



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Health participants over 18 years, that previously participated in VitmaD intervention study

Exclusion Criteria:

  • skindiseases
  • intake of medicin that causes photosensitive skin
  • pregnant or nursing
  • sun vacation 3 month before the intervention
  • intake of vitamin D supplement 3 month before the intervention

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01741233


Locations
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Denmark
Bispebjerg Hospital
Bispebjerg, Copenhagen, Denmark, 2400
DTU / National Food Institute
Morkhoj, Søborg, Denmark, 2860
Sponsors and Collaborators
Technical University of Denmark
Bispebjerg Hospital
Investigators
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Principal Investigator: Lone Rasmussen, M.Sc., Ph.D. DTU, Denmark
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Lone Banke Rasmussen, M.Sc., Ph.D., Technical University of Denmark
ClinicalTrials.gov Identifier: NCT01741233    
Other Study ID Numbers: H-4-2012-071
First Posted: December 4, 2012    Key Record Dates
Last Update Posted: August 1, 2013
Last Verified: December 2012
Keywords provided by Lone Banke Rasmussen, Technical University of Denmark:
SNPs
vitamin D
Vitamin D status
UVB irradiation
genetics
Additional relevant MeSH terms:
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Vitamin D Deficiency
Avitaminosis
Deficiency Diseases
Malnutrition
Nutrition Disorders