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The Effect of tDCS on Motor Performance and Cortical Excitability

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ClinicalTrials.gov Identifier: NCT01740843
Recruitment Status : Completed
First Posted : December 4, 2012
Last Update Posted : February 25, 2014
Sponsor:
Information provided by (Responsible Party):
Koen Cuypers, Hasselt University

Brief Summary:
In this study the effect of tDCS intensity on motor performance and corticospinal (CS) excitability is evaluated. The investigators expect that a positive relationship between current intensity and motor performance/CS excitability.

Condition or disease Intervention/treatment Phase
Cortical Excitability Motor Performance tDCS Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Study Start Date : August 2012
Actual Primary Completion Date : April 2013
Actual Study Completion Date : June 2013

Arm Intervention/treatment
Active Comparator: Low intensity anodal tDCS
tDCS will be administered for 10 min at 1mA
Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator)
The anode is fixed on the primary cortex and the cathode will be fixed on the contralateral supraorbital region.
Other Name: NeuroConn DC-stimulator

Experimental: High intensity anodal tDCS
tDCS will be administered for 10 min at 2.5mA
Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator)
The anode is fixed on the primary cortex and the cathode will be fixed on the contralateral supraorbital region.
Other Name: NeuroConn DC-stimulator

Sham Comparator: Sham tDCS
Sham will be administered for 10 min at 0 mA
Device: transcranial direct current stimulation (tDCS) (NeuroConn DC-stimulator)
The anode is fixed on the primary cortex and the cathode will be fixed on the contralateral supraorbital region.
Other Name: NeuroConn DC-stimulator




Primary Outcome Measures :
  1. Change in motor performance [ Time Frame: Baseline and POST (30 min after baseline) intervention ]
    motor performance is assessed using different reaction time paradigms (simple reaction time, choice reaction time). This is done at baseline and immediately after the intervention (30 min after baseline)

  2. Change in cortical excitability [ Time Frame: Baseline and POST (30 min after baseline) intervention ]
    Cortical excitability is measured using trancranial magnetic stimulation (TMS) measuring muscle evoked potentials (MEPs) at baseline and POST (30 min after baseline).



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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

- Healthy subjects

Exclusion Criteria:

  • Contraindications for tDCS/TMS
  • TMS measurements have to be possible
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Responsible Party: Koen Cuypers, Drs. Koen Cuypers, Hasselt University
ClinicalTrials.gov Identifier: NCT01740843    
Other Study ID Numbers: MECU2012-004
First Posted: December 4, 2012    Key Record Dates
Last Update Posted: February 25, 2014
Last Verified: February 2014