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The Effect of Anodal tDCS on Motor Learning in Multiple Sclerosis

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ClinicalTrials.gov Identifier: NCT01740830
Recruitment Status : Completed
First Posted : December 4, 2012
Last Update Posted : June 4, 2013
Sponsor:
Information provided by (Responsible Party):
Koen Cuypers, Hasselt University

Brief Summary:
The current study investigates the effects of tDCS in patients with multiple sclerosis (MS). The investigators hypothesize that anodal tDCS will increase motor performance in patients with MS.

Condition or disease Intervention/treatment Phase
Anodal tDCS Recruitment Curves Device: Transcranial Direct Current Stimulation (tDCS) (Neuroconn DC-stimulator) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 31 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Study Start Date : June 2012
Actual Primary Completion Date : October 2012
Actual Study Completion Date : October 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Anodal tDCS Device: Transcranial Direct Current Stimulation (tDCS) (Neuroconn DC-stimulator)
The anode will be fixed over the primary motor cortex. The cathode will be fixed over the contralateral supraorbital region.
Other Name: Neuroconn DC-stimulator

Sham Comparator: Sham tDCS Device: Transcranial Direct Current Stimulation (tDCS) (Neuroconn DC-stimulator)
The anode will be fixed over the primary motor cortex. The cathode will be fixed over the contralateral supraorbital region.
Other Name: Neuroconn DC-stimulator




Primary Outcome Measures :
  1. Motor performance on a unimanual sequence learning task [ Time Frame: Baseline, during training and POST (30 min after baseline) intervention ]
    Patients were instructed to perform a unimanual sequence-learning task consisting of sequential finger presses. The following parameters were measured: Correct sequences/mean inter tap interval (ITI), percentage correct key presses/mean ITI, percentage correct sequences, percentage correct key presses, mean ITI, and mean correct sequences in the performance interval.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • at least 18 years old
  • male and female

Exclusion Criteria:

  • relapse in the last 3 months
  • when not suitable for tDCS (screening)
  • if TMS measures can not be completed
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Responsible Party: Koen Cuypers, Drs. Koen Cuypers, Hasselt University
ClinicalTrials.gov Identifier: NCT01740830    
Other Study ID Numbers: MECU2012-003
First Posted: December 4, 2012    Key Record Dates
Last Update Posted: June 4, 2013
Last Verified: June 2013