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Sugar Sweetened Beverages (SSB)- Effects on Metabolism

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ClinicalTrials.gov Identifier: NCT01733563
Recruitment Status : Completed
First Posted : November 27, 2012
Last Update Posted : May 12, 2016
Sponsor:
Collaborators:
SNF Swiss National Foundation
University of Lausanne
Information provided by (Responsible Party):
University of Zurich

Study Description
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Brief Summary:
The objective of this study is to investigate the impact of sugar sweetened beverages on the fat metabolism of healthy young men. It is well known that consumption of beverages sweetened with fructose is associated with different health risks such as type 2 diabetes. The present study has been designed to dissect differences in the metabolic pathways of fructose and glucose, but also metabolic adaptations during fructose, glucose and sucrose diets. During a period of seven weeks subjects will consume either fructose, glucose or sucrose sweetened beverages or continue their usual drinking habits. During these seven weeks there will be different metabolic investigations using stable isotope tracers. First, the rate of lipolysis and beta-oxidation will be determined. Second, the rates of fatty acid synthesis will be measured. During all examinations there will also be substrate- and energy-utilization measurements by indirect calorimetry, blood analysis and morphometric measurements. Based on the literature main hypotheses are: Fructose enhances de novo lipogenesis postprandially and also in the fasting state significantly more than glucose by enhanced expression of lipogenic enzymes. Fructose decreases beta oxidation via downregulation of oxidative enzymes.

Condition or disease Intervention/treatment Phase
Metabolism Procedure: Soft drink consumption Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 96 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Effects of Carbohydrate Containing Diets on Lipid Metabolism & Fatty Acid Oxidation in Healthy Young Men - a Randomized, Double-Blinded Study.
Study Start Date : April 2013
Actual Primary Completion Date : May 2016
Actual Study Completion Date : May 2016
Arms and Interventions
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Arm Intervention/treatment
Experimental: fructose sweetened beverage

Soft drink consumption:

Subjects have to drink a fructose sweetened beverage (3x 200ml per day, 13.3g fructose/100ml) during 7 weeks

 Procedure: Soft drink consumption
Experimental: glucose sweetened beverage

Soft drink consumption:

Subjects have to drink a glucose sweetened beverage (3x 200ml per day, 13.3g glucose/100ml) during 7 weeks

 Procedure: Soft drink consumption
Experimental: sucrose sweetened beverage

Soft drink consumption:

Subjects have to drink a sucrose sweetened beverage (3x 200ml per day, 13.3g sucrose/100ml) during 7 weeks

 Procedure: Soft drink consumption
Experimental: No change of eating habits

No Soft drink consumption (no soft drink diet):

Subjects do not change their eating habits during 7 weeks

 Procedure: Soft drink consumption


Outcome Measures
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Primary Outcome Measures :
  1. Lipogenesis [ Time Frame: After total 6 weeks dietary intervention ]
    Measurement of lipogenesis is based on i. v. administration of stable isotope labelled acetate (1,2-13C-acetate). 13C incorporation into palmitate is quantified by mass-spectrometry. 13C incorporation correlates to the rate of fatty acid synthesis.


Secondary Outcome Measures :
  1. Lipolysis [ Time Frame: After total 6 weeks dietary intervention ]
    Measurements using stable isotopes


Other Outcome Measures:
  1. Waist/Hip Ratio [ Time Frame: After total 6 weeks dietary intervention ]
    Measurement waist/hip ratio using a nonstretchable band


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion criteria:

  • Healthy male volunteers aged 18-30
  • BMI between 19-24 kg/m2
  • Non-smoker

Exclusion criteria:

  • Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
  • Diabetes
  • Known alcohol, substance or drug abuse, concomitant medication
  • More than three hours of physical exercise per week
  • Consumption of more than 2 times 3 dl SSB daily
  • Subjects likely to fail to comply with the study protocol
  • Subjects who do not give informed consent
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01733563


Locations
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Switzerland
University Hospital Zurich, Endocrinology and Diabetology
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
SNF Swiss National Foundation
University of Lausanne
Investigators
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Principal Investigator: Philipp Gerber, MD University Hospital Zurich, Endocrinology and Diabetology
More Information
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Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT01733563    
Other Study ID Numbers: SSB-Effects on metabolism
First Posted: November 27, 2012    Key Record Dates
Last Update Posted: May 12, 2016
Last Verified: May 2016
Keywords provided by University of Zurich:
sugar sweetened beverages
fructose
lipogenesis
beta-oxidation