Sugar Sweetened Beverages (SSB)- Effects on Metabolism
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ClinicalTrials.gov Identifier: NCT01733563 |
Recruitment Status :
Completed
First Posted : November 27, 2012
Last Update Posted : May 12, 2016
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Metabolism | Procedure: Soft drink consumption | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 96 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Prevention |
Official Title: | Effects of Carbohydrate Containing Diets on Lipid Metabolism & Fatty Acid Oxidation in Healthy Young Men - a Randomized, Double-Blinded Study. |
Study Start Date : | April 2013 |
Actual Primary Completion Date : | May 2016 |
Actual Study Completion Date : | May 2016 |
Arm | Intervention/treatment |
---|---|
Experimental: fructose sweetened beverage
Soft drink consumption: Subjects have to drink a fructose sweetened beverage (3x 200ml per day, 13.3g fructose/100ml) during 7 weeks |
Procedure: Soft drink consumption |
Experimental: glucose sweetened beverage
Soft drink consumption: Subjects have to drink a glucose sweetened beverage (3x 200ml per day, 13.3g glucose/100ml) during 7 weeks |
Procedure: Soft drink consumption |
Experimental: sucrose sweetened beverage
Soft drink consumption: Subjects have to drink a sucrose sweetened beverage (3x 200ml per day, 13.3g sucrose/100ml) during 7 weeks |
Procedure: Soft drink consumption |
Experimental: No change of eating habits
No Soft drink consumption (no soft drink diet): Subjects do not change their eating habits during 7 weeks |
Procedure: Soft drink consumption |
- Lipogenesis [ Time Frame: After total 6 weeks dietary intervention ]Measurement of lipogenesis is based on i. v. administration of stable isotope labelled acetate (1,2-13C-acetate). 13C incorporation into palmitate is quantified by mass-spectrometry. 13C incorporation correlates to the rate of fatty acid synthesis.
- Lipolysis [ Time Frame: After total 6 weeks dietary intervention ]Measurements using stable isotopes
- Waist/Hip Ratio [ Time Frame: After total 6 weeks dietary intervention ]Measurement waist/hip ratio using a nonstretchable band

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Ages Eligible for Study: | 18 Years to 30 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
- Healthy male volunteers aged 18-30
- BMI between 19-24 kg/m2
- Non-smoker
Exclusion criteria:
- Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
- Diabetes
- Known alcohol, substance or drug abuse, concomitant medication
- More than three hours of physical exercise per week
- Consumption of more than 2 times 3 dl SSB daily
- Subjects likely to fail to comply with the study protocol
- Subjects who do not give informed consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01733563
Switzerland | |
University Hospital Zurich, Endocrinology and Diabetology | |
Zurich, ZH, Switzerland, 8091 |
Principal Investigator: | Philipp Gerber, MD | University Hospital Zurich, Endocrinology and Diabetology |
Responsible Party: | University of Zurich |
ClinicalTrials.gov Identifier: | NCT01733563 |
Other Study ID Numbers: |
SSB-Effects on metabolism |
First Posted: | November 27, 2012 Key Record Dates |
Last Update Posted: | May 12, 2016 |
Last Verified: | May 2016 |
sugar sweetened beverages fructose lipogenesis beta-oxidation |