High Intensity Interval Training (HIT) in Patients With Type 2 Diabetes (HIT_T2DM)
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ClinicalTrials.gov Identifier: NCT01732705 |
Recruitment Status :
Completed
First Posted : November 26, 2012
Last Update Posted : December 31, 2014
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Condition or disease | Intervention/treatment | Phase |
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Type 2 Diabetes | Behavioral: High intensity interval training | Not Applicable |
Physical exercise increases insulin sensitivity in skeletal muscle in healthy as well as in individuals with type 2 diabetes, but implies a considerable time commitment. High intensity interval training (HIT) is time-efficient exercise consisting of repeated bouts of short duration high intensive workloads. The aim of this study is to determine the effect of HIT in patients with type 2 diabetes, and to clarify the mechanisms of a possible positive effect of HIT.
Exercise is performed as 2 weeks one-legged training on an ergometer bicycle. Thus one leg serves as a control leg. Insulin sensitivity in trained and non-trained muscle will be measured after completion of the overall training program by euglycemic hyperinsulinemic clamp method and a-v catheterization of both legs. Muscle biopsies will be obtained during training period for measuring of muscle glycogen content, and muscle biopsies for further analysis obtained during the experimental day.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 20 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Effect of High Intensity Interval Training (HIT) on Insulin Sensitivity in Patients With Type 2 Diabetes |
Study Start Date : | September 2012 |
Actual Primary Completion Date : | December 2014 |
Actual Study Completion Date : | December 2014 |

Arm | Intervention/treatment |
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Experimental: HIT (trained leg) DM
High intensity interval training for one leg (trained leg) (randomized) in patient with type 2 diabetes
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Behavioral: High intensity interval training
HIT will be conducted as 2 weeks of one legged high intense interval training (8 sessions every 2nd day). Each training session will consist of 10 x 1 min intervals on ergometer bicycle interspersed with 1 min recovery.
Other Names:
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No Intervention: Control leg, DM
Control leg (untrained leg)in patient with type 2 diabetes
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Experimental: HIT (trained leg), Control subject
High intensity interval training for one leg (trained leg) (randomized) in control subject
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Behavioral: High intensity interval training
HIT will be conducted as 2 weeks of one legged high intense interval training (8 sessions every 2nd day). Each training session will consist of 10 x 1 min intervals on ergometer bicycle interspersed with 1 min recovery.
Other Names:
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No Intervention: Control leg, Control subject
Control leg (untrained leg)in control subject
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- Insulin sensitivity [ Time Frame: 2 days after last training session (day 17) ]Insulin sensitivity in trained and non-trained muscle will be measured by euglycemic hyperinsulinemic clamp method and a-v catheterization of both legs.
- Glycogen content in skeletal muscle [ Time Frame: 17 days. Before and after training session day 1, 7 and 15. Before and immediately after isoglycemic, hyperinsulinemic clamp day 17. ]Analysis of glycogen content from muscle biopsies taken during the training period.

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Ages Eligible for Study: | 40 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- 10 subjects with Type 2 diabetes. 10 healthy control subjects.
- BMI 28-35
- diet or tablet treatment for diabetes
Exclusion Criteria:
- regular physical activity
- diseases other than type 2 diabetes
- insulin treatment

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01732705
Denmark | |
Xlab, Department of Biomedical Sciences, University of Copenhagen | |
Copenhagen N, Denmark, 2200 |
Principal Investigator: | Flemming Dela, MD. Prof. | Xlab, Department of Biomedical Sciences, University of Copenhagen |
Responsible Party: | Flemming Dela, Professor, MD., University of Copenhagen |
ClinicalTrials.gov Identifier: | NCT01732705 |
Other Study ID Numbers: |
HIT-T2DM |
First Posted: | November 26, 2012 Key Record Dates |
Last Update Posted: | December 31, 2014 |
Last Verified: | December 2014 |
Type 2 diabetes Insulin sensitivity High intensity interval training |
Diabetes Mellitus Diabetes Mellitus, Type 2 Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases |