Hemifacial Spasm and Desflurane (HFS)
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|ClinicalTrials.gov Identifier: NCT01726725|
Recruitment Status : Unknown
Verified November 2012 by University of Manitoba.
Recruitment status was: Enrolling by invitation
First Posted : November 15, 2012
Last Update Posted : November 16, 2012
|Condition or disease||Intervention/treatment|
|Hemifacial Spasm||Drug: desflurane|
"Intra Operative Monitoring" (IOM) is a standard and routine medical practice for patients having MVD surgery. IOM is done to make sure that the hearing and face nerves are not accidentally bumped or damaged during surgery. After anesthetic induction, the neurophysiologist places electrodes for the nerves, on the scalp and muscles. Stimulation and monitoring of muscle twitches are all common, safe and painless medical procedures.
In this study, the investigators would like to measure the nerve and muscle function on the normal side and compare it to nerve and muscle function on the abnormal side during different levels of the anesthetic desflurane. In order to monitor the normal side of the face one additional set of electrodes will be placed in the facial muscles. The investigators will compare responses to three different levels of anesthetic. The technique used will be motor evoked potentials. The effect of the anesthesia on the lateral spread response will also be examined. This response is evident only on the symptomatic side. These observations will take approximately 10 to 15 minutes and will not delay or lengthen the surgery.
|Study Type :||Observational|
|Estimated Enrollment :||25 participants|
|Observational Model:||Case Control|
|Official Title:||Investigating the Etiology of Hemifacial Spasm (HFS): The Role of Desflurane|
|Study Start Date :||November 2012|
|Estimated Primary Completion Date :||December 2013|
|Estimated Study Completion Date :||December 2013|
hemifacial spasm, lateral spread, motor evoked potentials
EMG recordings from facial muscles of HFS patients during MVD surgery will be compared during total intravenous anesthesia (propofol), 0.5 MAC desflurane and 1.0 MAC desflurane
- Measure EMG responses to peripheral nerve stimulation and motor cortex stimulation during changes in desflurane levels [ Time Frame: one year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01726725
|Principal Investigator:||Marshall Wilkinson, PhD||University of Manitoba|