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Histopathology of the Aspirated Thrombus During Acute Myocardial Infarction

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ClinicalTrials.gov Identifier: NCT01705665
Recruitment Status : Unknown
Verified October 2012 by Hillel Yaffe Medical Center.
Recruitment status was:  Recruiting
First Posted : October 12, 2012
Last Update Posted : October 23, 2012
Sponsor:
Information provided by (Responsible Party):
Hillel Yaffe Medical Center

Brief Summary:
This study was initiated on the preliminary premise that a thrombus whose formation was triggered by a thrombogenic substrate, such as within an atherosclerotic plaque (Tissue factor initiated thrombus), may evolve differently than the one evolving at the site of a recently implanted stent (foreign body triggered). Consequently, the thrombus composition of a de novo clot could differ from the other one, extracted during the occurrence of a subacute thrombosis, regarding the number of various cells, the amount of fibrin and platelet aggregates and the relationship among these components. In addition, it seems relevant to evaluate the numbers and the distribution of the local monocytes, once these cells may interact with platelets (via cell -adhesion mechanisms e.g., by CD31 [PECAM-1]) and by the extrinsic coagulation pathway (via TF/FVII elaborated by plaque-resident macrophages). Such a distinction, if eventually found, may reveal the mechanisms of thrombosis within coronary arteries, and may have clinical implications.

Condition or disease
Thrombosis Acute Coronary Syndrome

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : January 2012
Estimated Primary Completion Date : December 2013
Estimated Study Completion Date : December 2013

Resource links provided by the National Library of Medicine


Group/Cohort
Aspirated Coronary Thrombi During AMI



Primary Outcome Measures :
  1. Evaluation of Possible Difference in Composition of Thrombi Aspirated during Acute Myocardial Infarction Precipitated by de novo vs Subacute Thrombosis [ Time Frame: two years ]
    Analysis of thrombotic specimen contents aspirated during Acute Myocardial Infarction by searching for possible differences in the components of the thrombotic debris, whether cellular, or fibrin and platelets, in accordance with clinical parameters.



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients admitted for an acute coronary syndrome who undergo angiography, found to have a coronary thrombosis that is aspirated and which yields thrombus fragments.
Criteria

Inclusion Criteria:

  • Patients with acute coronary syndrome who undergo angiography
  • Evidence of coronary thrombus
  • Undergo aspiration procedure yielding thrombus fragments

Exclusion Criteria:

-


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01705665


Locations
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Israel
Heart Institute, Hillel Yaffe Medical Center Recruiting
Hadera, Israel, 38100
Contact: Simcha R Meisel, MD, MSc    972-4-6304470    meisel@hy.health.gov.il   
Principal Investigator: Simcha R Meisel, MD, MSc         
Sub-Investigator: Mary Amar, MD         
Sub-Investigator: Edmond Sabo, MD         
Sponsors and Collaborators
Hillel Yaffe Medical Center

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Responsible Party: Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT01705665     History of Changes
Other Study ID Numbers: HYMC-70-10
First Posted: October 12, 2012    Key Record Dates
Last Update Posted: October 23, 2012
Last Verified: October 2012
Additional relevant MeSH terms:
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Thrombosis
Acute Coronary Syndrome
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Myocardial Ischemia
Heart Diseases