Angina Prevalence and Provider Evaluation of Angina Relief (APPEAR)

• ClinicalTrials.gov Identifier: NCT01705054
• Recruitment Status: Completed
• First Posted: October 12, 2012
• Last Update Posted: June 22, 2017
• Sponsor: Saint Luke's Health System
• Collaborator: Gilead Sciences
• Information provided by (Responsible Party): John A. Spertus, MD, MPH, Saint Luke's Health System

Study Description

Brief Summary:

The purpose of this study is describe the frequency of chest pain and how chest pain impacts patients' quality of life in the outpatients with chronic coronary artery disease in contemporary cardiology practice settings.

Condition or disease
Stable Coronary Artery Disease CAD

Detailed Description:

The primary goals in the management of stable coronary artery disease (CAD) are to reduce risk factors for heart attack and to control the symptoms of angina (chest pain). Ideally angina is well controlled with medications alone, but invasive procedures are a valuable option for patients with persistent angina. The amount of angina among patients with stable CAD in the outpatient setting, however, is unknown. An Australian study reported that almost 1 in 3 patients with stable angina being treated by primary care doctors had angina at least once a week, which was associated with worse quality of life. We propose to examine the burden of angina in outpatients with stable CAD who are being medically managed by cardiologists in the United States through administration of a one-time survey. The information from this study could ultimately help improve management of stable CAD and angina and illuminate potential underuse of revascularization. While cardiologists are generally expected to provide better angina control than primary care doctors, establishing the prevalence of angina among the best providers will help with a framework for interpreting symptom control among other practitioners.

Study Design

• Study Type: Observational
• Actual Enrollment: 1246 participants
• Observational Model: Case-Only
• Time Perspective: Prospective
• Official Title: Angina Prevalence and Provider Evaluation of Angina Relief
• Study Start Date: July 2013
• Actual Primary Completion Date: July 2015
• Actual Study Completion Date: July 22, 2015

Groups and Cohorts

Group/Cohort
Outpatient Coronary Artery Disease Patient; CAD patients being seen in a participating cardiology office for a scheduled clinic visit who agree to take the survey.

Outcome Measures

Primary Outcome Measures :

1. Seattle Angina Questionnaire [ Time Frame: One time cardiology office visit. ]
   Percentage of patients with frequent angina (>1 episode/week) as measured by the Seattle Angina Questionnaire (SAQ).

Secondary Outcome Measures :

1. Quality of Life [ Time Frame: One time cardiology office visit. ]
   Evaluate the impact of frequent angina on Quality of Life (as measured by the SAQ)
2. Physician Perspective [ Time Frame: One time cardiology office visit. ]
   Identifying differences between patients' and cardiologists' assessment of angina control
3. Cardiology practices angina control. [ Time Frame: One time cardiology office visit. ]
   Evaluate the differences in angina control between cardiology practices.

Eligibility Criteria

• Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No
• Sampling Method: Non-Probability Sample

Study Population

Outpatient cardilogy practice.

Criteria

Inclusion Criteria:

• Coronary artery disease patients being seen in a participating cardiology office for a scheduled clinic visit who agree to take the survey.

Exclusion Criteria:

• Too ill to take survey
• Previously completed this survey
• Refused to participate

Contacts and Locations

Locations

United States, Missouri

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, United States, 64111

Sponsors and Collaborators

Saint Luke's Health System

Gilead Sciences

Investigators

• Principal Investigator: John A Spertus, MD, MPH; Saint Luke's Hospital of Kansas City
• Principal Investigator: Faraz Kureshi, MD; Saint Luke's Hospital of Kansas City

More Information

Publications:

Beltrame JF, Weekes AJ, Morgan C, Tavella R, Spertus JA. The prevalence of weekly angina among patients with chronic stable angina in primary care practices: The Coronary Artery Disease in General Practice (CADENCE) Study. Arch Intern Med. 2009 Sep 14;169(16):1491-9. doi: 10.1001/archinternmed.2009.295.

• Responsible Party: John A. Spertus, MD, MPH, Missouri/Lauer Endowed Chair and Tenured Professor of Medicine, Saint Luke's Health System
• ClinicalTrials.gov Identifier: NCT01705054
• Other Study ID Numbers: IN-US-259-0157
• First Posted: October 12, 2012
• Last Update Posted: June 22, 2017
• Last Verified: June 2017

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: No

Keywords provided by John A. Spertus, MD, MPH, Saint Luke's Health System:

Angina; Stable ischemic heart disease; Quality of Life; Seattle Angina Questionnaire (SAQ)

Additional relevant MeSH terms:

Coronary Artery Disease; Angina Pectoris; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms