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Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01699802
Recruitment Status : Completed
First Posted : October 4, 2012
Last Update Posted : May 14, 2015
Information provided by (Responsible Party):
Region Skane

Brief Summary:

The purpose is to investigate how the adsorptive capacity of the active carbon filter to carbon dioxide in an anaesthetic gas reflector (AnaConDa) is affected by adding inhaled anaesthetic agent.

The hypothesis is that addition of inhaled anaesthetic agent will affect the amount of adsorption of carbon dioxide to the active carbon and thereby affect rebreathing of carbon dioxide.

Condition or disease Intervention/treatment Phase
Ischemic Heart Disease Other: Inhaled anaesthetic agent Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
Study Start Date : September 2012
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Arm Intervention/treatment
Experimental: Inhaled anaesthetic agent
The group where the investigators adds inhaled anaesthetic agent when using the anaesthetic gas reflector (AnaConda).
Other: Inhaled anaesthetic agent

Primary Outcome Measures :
  1. Volume of carbon dioxide rebreathing from an anesthetic gas reflector [ Time Frame: 2 hours ]
    Tidal carbon dioxide volume rebreathed from an anesthetic gas reflector correlated to concentration of delivered anesthetic gas.

Secondary Outcome Measures :
  1. Quantification of ventilatory requirements to maintain isocapnia with the use of an anesthetic gas reflector. [ Time Frame: 2 hours ]
    Changes of tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value.

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • elective coronary artery by-pass graft surgery
  • elective valve replacement surgery
  • normal left ventricular ejection fraction on preoperative echocardiography

Exclusion Criteria:

  • obstructive lung disease
  • restrictive lung disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01699802

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Skane University Hospital Lund, Cardiothoracic Intensive Care
Lund, Sweden, SE-221 85
Sponsors and Collaborators
Region Skane
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Principal Investigator: Mikael Bodelsson, Professor Divison of Surgery, Department of Anaesthesia, Skane University Hospital, Lund, Sweden

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Responsible Party: Region Skane Identifier: NCT01699802     History of Changes
Other Study ID Numbers: 2012/148
First Posted: October 4, 2012    Key Record Dates
Last Update Posted: May 14, 2015
Last Verified: May 2015
Additional relevant MeSH terms:
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Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arterial Occlusive Diseases
Central Nervous System Depressants
Physiological Effects of Drugs