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Pseudoexfoliation and Chronic Kidney Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01693744
Recruitment Status : Completed
First Posted : September 26, 2012
Last Update Posted : September 26, 2012
Information provided by (Responsible Party):
Leyla Niyaz, Corum State Hospital

Brief Summary:

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

Condition or disease
Chronic Kidney Disease

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Study Type : Observational
Actual Enrollment : 358 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: The Relationship Between Pseudoexfoliation and Chronic Kidney Disease
Study Start Date : October 2011
Actual Study Completion Date : April 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases

Dialysis patients
Patients with stage 5 chronic kidney disease undergoing haemodialysis
Chronic kidney disease patients
Stage 1-4 Chronic kidney disease patients
Control group
Patients with normal renal functions

Primary Outcome Measures :
  1. Prevalance of pseudoexfoliation in patients with chronic kidney disease [ Time Frame: 7 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients from nephrology clinic

Inclusion Criteria:

  • All patients with chronic kidney disease stage 1-5

Exclusion Criteria:

  • History of eye trauma or surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01693744

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Corum State Hospital
Corum, Turkey, 19000
Sponsors and Collaborators
Corum State Hospital
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Principal Investigator: Leyla Niyaz, M.D. Specialist in Ophthalmology
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Responsible Party: Leyla Niyaz, Ophthalmology Specialist, Corum State Hospital Identifier: NCT01693744    
Other Study ID Numbers: LNiyaz
First Posted: September 26, 2012    Key Record Dates
Last Update Posted: September 26, 2012
Last Verified: September 2012
Keywords provided by Leyla Niyaz, Corum State Hospital:
Pseudoexfoliation, chronic kidney disease
Additional relevant MeSH terms:
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Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency