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Immune Response in the SAPHO Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01688219
Recruitment Status : Completed
First Posted : September 19, 2012
Last Update Posted : September 19, 2012
Information provided by (Responsible Party):
Assistance Publique - Hôpitaux de Paris

Brief Summary:
The aetiology of SAPHO syndrome seems to involve genetic, infectious and immunological components. The investigators examined innate and adaptative immune responses in SAPHO syndrome as compared with psoriatic arthritis and rheumatoid arthritis.

Condition or disease
SAPHO Syndrome

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Study Type : Observational
Actual Enrollment : 39 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Immune Mechanisms During SAPHO Syndrome and Treatment by Etarnecept
Study Start Date : November 2005
Actual Study Completion Date : May 2008

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. IL-8 production by PMN [ Time Frame: 24 h ]

Secondary Outcome Measures :
  1. TNFalpha production by PMN [ Time Frame: 24 h ]

Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year to 70 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
SAPHO syndrome patients

Inclusion Criteria:

  • Clinical diagnosis of SAPHO syndrome
  • Must have bone lesions

Exclusion Criteria:

  • Infliximab treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01688219

Sponsors and Collaborators
Assistance Publique - Hôpitaux de Paris
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Study Director: Gilles Hayem, PhD Assitance Publique-Hopitaux Paris
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Responsible Party: Assistance Publique - Hôpitaux de Paris Identifier: NCT01688219    
Other Study ID Numbers: 45896566645469
First Posted: September 19, 2012    Key Record Dates
Last Update Posted: September 19, 2012
Last Verified: October 2007
Keywords provided by Assistance Publique - Hôpitaux de Paris:
SAPHO syndrome
Innate immunity
TNF alpha
Polymorphonuclear neutrophils
Propionibacterium acnes
Additional relevant MeSH terms:
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Acquired Hyperostosis Syndrome
Pathologic Processes
Bone Diseases, Developmental
Bone Diseases
Musculoskeletal Diseases