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Free Fatty Acids: Short Exposure Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01686113
Recruitment Status : Completed
First Posted : September 17, 2012
Last Update Posted : November 21, 2014
Information provided by (Responsible Party):
Richard Mattes, Purdue University

Brief Summary:
This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.

Condition or disease Intervention/treatment Phase
Hypogeusia Other: NEFA Other: Sucrose Not Applicable

Detailed Description:
The possibility that humans can taste non-esterified fatty acids (NEFA) - so-called fat taste - is a relatively new area of research. Previous work suggests that subjects require an average of between two and three testing sessions of approximately an hour each before they can reliably detect NEFA, and the average number of visits to get the lowest threshold is six. Streamlining this process is of great interest to researchers who wish to test many people as quickly as possible. Other taste qualities, including umami and sweet, have shown improvement in detection sensitivity in subjects that have undergone ten second exposures to these taste qualities for 10 days upon subsequent re-testing. We seek to determine if the same improvements can be seen with fat taste.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Free Fatty Acids: Short Exposure Study
Study Start Date : May 2012
Actual Primary Completion Date : May 2014
Actual Study Completion Date : May 2014

Arm Intervention/treatment
Experimental: NEFA
Participants swish and spit 5 mL of an oleic acid solution everyday for 10 days.
Other: NEFA
Other Name: Oleic acid

Active Comparator: Control
Participants swish and spit 5 mL of sucrose solution everyday for 10 days.
Other: Sucrose

Primary Outcome Measures :
  1. NEFA detection threshold [ Time Frame: 10 days ]

Secondary Outcome Measures :
  1. Hunger [ Time Frame: 2 days ]
    Visual analog scale assessment of hunger level prior to testing

  2. BMI [ Time Frame: 1 day ]
  3. Taste descriptor [ Time Frame: 10 days ]
    Description of NEFA taste by participant, e.g., sour, bitter, etc.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • good health
  • available for multiple testing visits

Exclusion Criteria:

  • have participated in a fat taste study in the past 6 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01686113

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United States, Indiana
Purdue University
West Lafayette, Indiana, United States, 47907
Sponsors and Collaborators
Purdue University
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Principal Investigator: Richard D Mattes, PhD Purdue University
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Responsible Party: Richard Mattes, Distinguished Prof Foods and Nutrition, Purdue University Identifier: NCT01686113    
Other Study ID Numbers: 1205012317
First Posted: September 17, 2012    Key Record Dates
Last Update Posted: November 21, 2014
Last Verified: November 2014
Keywords provided by Richard Mattes, Purdue University:
Fat Taste
Threshold Testing
Additional relevant MeSH terms:
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Taste Disorders
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms