Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)
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ClinicalTrials.gov Identifier: NCT01682382 |
Recruitment Status :
Completed
First Posted : September 10, 2012
Last Update Posted : January 20, 2014
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Condition or disease |
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Age-related Macular Degeneration Choroidal Neovascular Age-related Macular Degeneration |
Study Type : | Observational |
Actual Enrollment : | 45 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Collection of Whole Blood Specimens and Buccal Swabs From Subjects Diagnosed With CNV AMD, Dry AMD, and Age-Matched Controls to Assess the Association of Genetic Variants in Complement Factor H With Risk of Progression to CNV. |
Study Start Date : | August 2012 |
Actual Primary Completion Date : | August 2013 |
Actual Study Completion Date : | October 2013 |

Group/Cohort |
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choroidal neovascular (CNV) AMD subjects
Subjects diagnosed with CNV (AREDS Grade 4b)
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dry AMD subjects
Subjects diagnosed with dry AMD (AREDS Grade 3)
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age-matched controls
Subjects without AMD (AREDS Grade 1)
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- Association between a genetic variant in the CFH gene and risk of progression to CNV [ Time Frame: Baseline ]DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate a genetic variant in the CFH gene and its association with risk of progression to CNV
- Genetic correlation between MPOD and risk of progression to CNV [ Time Frame: baseline ]DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate the correlation between genetics, MPOD, and risk of progression to CNV
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 60 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- subject is diagnosed with either CNV, dry AMD or is an age-matched control
- self reported as non-Hispanic Caucasian
- 60 years of age or older
- provides signed and dated informed consent
- agrees to provide 10 mL of whole blood and two buccal swabs
Exclusion Criteria:
- previous donation under this protocol

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01682382
United States, California | |
Morris Eye Group | |
Encinitas, California, United States, 92024 |
Responsible Party: | Sequenom, Inc. |
ClinicalTrials.gov Identifier: | NCT01682382 |
Other Study ID Numbers: |
SQNM-AMD-103 |
First Posted: | September 10, 2012 Key Record Dates |
Last Update Posted: | January 20, 2014 |
Last Verified: | January 2014 |
age-related macular degeneration choroidal neovascular age-related macular degeneration genetics macular pigment optical density (MPOD) |
Macular Degeneration Wet Macular Degeneration Retinal Degeneration Retinal Diseases Eye Diseases |