Pressure Dependent Tracheal Obstruction in Copd Patients (PDTO)
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|ClinicalTrials.gov Identifier: NCT01679808|
Recruitment Status : Completed
First Posted : September 6, 2012
Last Update Posted : September 6, 2012
Background. Do pressure dependent tracheal obstructions (PDTO) often seen during bronchoscopy in COPD patients affect pulmonary function tests and breathing symptoms? Method. Model study. A garden hose was compressed from one side to simulate the posterior wall of the trachea bulging into the lumen. For two obstruction lengths - 3 cm and 12 cm, the hose was increasingly compressed in eight steps. Resistance was measured at each step for airflows 1 l/s through 9 l/s, and digital photos of the luminal area were taken which were used by a computer to estimate the cross sectional area reduction and the corresponding distance between the bulging (posterior)and the opposite (anterior) wall (AP-distance).
Patient study. 104 stable COPD patients studied by pulmonary function tests and bronchoscopy. The tracheal obstruction was observed during forced expiration and cough, and the cross sectional area reduction was estimated using the results from the model study.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||104 participants|
|Official Title:||Pressure Dependent Tracheal Obstruction in Copd Patients|
|Study Start Date :||August 2004|
|Actual Primary Completion Date :||August 2006|
|Actual Study Completion Date :||August 2011|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01679808
|Hakadal, Akershus, Norway, 1485|
|Principal Investigator:||Ivar Ellingsen, Dr med||LHL Helse|