MRS Probe Study of Alcohol
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01679444 |
Recruitment Status :
Completed
First Posted : September 6, 2012
Last Update Posted : June 30, 2014
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Heavy Dose Drinkers | Procedure: Magnetic Resonance Spectroscopy | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 40 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Official Title: | Magnetic Resonance Spectroscopy Probe Study of Alcohol Use |
Study Start Date : | August 2012 |
Actual Primary Completion Date : | March 2014 |
Actual Study Completion Date : | June 2014 |
- Procedure: Magnetic Resonance Spectroscopy
Other Name: MRS
- Utilizing Magnetic Resonance Spectroscopy at 3 Tesla, investigate the neurobiological underpinnings of alcohol cravingassessing baseline perturbations in anterior cingulate and ventral striatal metabolites (NAA levels, glutamate levels, glutamine levels)
- Evaluate the relationship between these metabolites, each reported as a Cerebrospinal Fluid-corrected absolute concentration, and severity of alcohol cravingsEvaluate the relationship between these metabolites, each reported as a Cerebrospinal fluid-corrected absolute concentration, and severity of alcohol cravings, as measured primarily by the Penn Alcohol Craving Scale and secondarily by the Inventory of Drug Taking Situations.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 21 Years to 70 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria: (Minimal or No Alcohol Group)
- Male or female age 21-70
- Consume less alcohol then what is described in this protocol as a "higher dose drinker", or consume no alcohol at all.
- Able to complete a 60 min. MRS brain scan.
Exclusion Criteria:
- Inability to speak English
- Inability or unwillingness to provide written informed consent
- Diagnosis of active substance dependence other than nicotine (e.g. alcohol, cannabis, caffeine, prescription use of barbiturates, benzodiazepines, opiates, or stimulants) this will be determined using a PRISM (Psychiatric Research Interview for Substance and Mental Disorders) interview.
- Any unstable active medical or additional psychiatric condition as determined by the investigator
- Active suicidal ideation as determined by the PHQ-9 question 9 indicating response #2 or higher (several days; more than half the days; or nearly every day).
- History of encephalopathy, hepatic failure, or HIV seropositivity
- History of claustrophobia
- History of major head trauma with loss of consciousness >5 minutes or skull fracture
- History of previous neurological event (e.g. epilepsy, stroke, transient ischemic attack)
- Implanted metal objects (e.g. pacemakers; aneurysm clips; metal prostheses, joints, rods, or plates)
- Contraindication to MRI scanning
- Pregnancy or breast-feeding

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01679444
United States, Minnesota | |
Mayo Clinic in Rochester | |
Rochester, Minnesota, United States, 55905 |
Principal Investigator: | Mark Frye, MD | Mayo Clinic |
Responsible Party: | Mark Frye, Principal Investigator, Mayo Clinic |
ClinicalTrials.gov Identifier: | NCT01679444 |
Other Study ID Numbers: |
12-003693 |
First Posted: | September 6, 2012 Key Record Dates |
Last Update Posted: | June 30, 2014 |
Last Verified: | June 2014 |
MRS Heavy dose drinkers Alcohol NIAAA |