MostCare Versus Echo-Doppler for Cardiac Output Measurement (PRAM)
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ClinicalTrials.gov Identifier: NCT01678950 |
Recruitment Status :
Completed
First Posted : September 5, 2012
Last Update Posted : June 25, 2014
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Condition or disease |
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Cardiac Output Measurement |

Study Type : | Observational |
Actual Enrollment : | 400 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Comparison Between MostCare and Echo-Doppler for Cardiac Output Measurement: an Observational Study |
Study Start Date : | June 2011 |
Actual Primary Completion Date : | June 2013 |
Actual Study Completion Date : | June 2013 |
- cardiac output [ Time Frame: comparison of monitoring systems ]comparison of cardiac output monitoring systems

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Patients equipped with a standard arterial catheter-line (femoral or radial artery) for invasive arterial blood pressure monitoring.
- Patients requiring an echocardiographic evaluation - Transthoracic Echocardiographic Evaluation (TEE)or Transesophageal Echocardiographic Evaluation (TOE) - as a routine need or in the context of Acute Cardiocirculatory failure with suspected implication of cardiac dysfunction or Acute Respiratory failure and suspicion of cardiac failure.
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*When a pulmonary artery catheter (PAC, standard bolus thermodilution, ThD) is used or a central venous catheter linked with a femoral artery catheter to measure the transpulmonary thermodilution (PiCCO system: Continuous pulse contour cardiac analysis), the comparison will be done as a secondary end point of the protocol.
- The point n.3 is optional
Exclusion Criteria:
- Related to MostCare:
pathologies that could affect the quality and reliability of the arterial signal (aortic valve pathologies, aortic aneurysms) and arrhythmias that generate hemodynamic instability (i.e., variations in mean BP measurements > 10%); poor quality of the arterial pressure signal after a standard flush test (i.e., over-damped or under-damped arterial trace).
- Related to Echo-Doppler: non-feasibility to obtain a fulfilled quality of the images.
- Patients younger than 18.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01678950
France | |
Department of Anesthesiology & Intensive Care - Lariboisière University Hospital University Paris 7 Diderot. France | |
Paris, France, 75007 | |
Italy | |
Department of Anaesthesia and Intensive Care, Torrette University Hospital | |
Ancona, Italy, 60100 | |
Intensive Care Unit, Santa Maria Annunziata Hospital | |
Florence, Italy, 50122 | |
Department of Cardiovascular Anesthesia and Intensive Care, Careggi University Hospital, Italy | |
Florence, Italy, 50141 | |
Anaesthesia and Intensive Care Unit, S. Giovanni di Dio - Torregalli Hospital | |
Florence, Italy, 50143 | |
Department of Anaesthesia and Intensive Care, Ospedali Riuniti Foggia University Hospital | |
Foggia, Italy, 71100 | |
Cardio-Thoracic-Vascular Anaesthesia and Intensive Care, San Raffaele University Hospital | |
Milan, Italy, 20132 | |
Policlinico Universitario Padova | |
Padova, Italy, 35128 | |
Department of Anaesthesia and Intensive Care, Pisa University Hospital | |
Pisa, Italy, 56126 | |
Ospedale S. Antonio Abate di Pontremoli | |
Pontremoli, Italy, 54027 | |
Cardiovascular Anesthesia, Policlinico Umberto I° | |
Rome, Italy, 00161 | |
Department of Anaesthesia and Intensive Care, Siena University Hospital | |
Siena, Italy, 53100 | |
Spain | |
of Anesthesia, Critical Care and Pain Medicine, Hospital Universitario de la Ribera | |
Valencia, Spain, 46600 | |
United Kingdom | |
(Cardiothoracic Anaesthesia, Heart and Lung Centre, New Cross Hospital | |
Wolverhampton, England, United Kingdom, WV10 |
Responsible Party: | Sabino Scolletta, MD, Principal Investigator, Azienda Ospedaliera Universitaria Senese |
ClinicalTrials.gov Identifier: | NCT01678950 |
Other Study ID Numbers: |
PRAM2012 |
First Posted: | September 5, 2012 Key Record Dates |
Last Update Posted: | June 25, 2014 |
Last Verified: | June 2014 |
Cardiac output monitoring Echocardiography Pulse contour system |