Relation Between Mixed Venous Oxygen Saturation and Cerebral Oxygen Saturation Measured by Absolute and Relative Near-infrared Spectroscopy During Off-pump Coronary Artery Bypass Grafting.
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|ClinicalTrials.gov Identifier: NCT01673841|
Recruitment Status : Completed
First Posted : August 28, 2012
Last Update Posted : August 29, 2012
In this clinical study the investigators compared mixed venous oxygen saturation (SmvO2) with relative and absolute cerebral oxygen saturation (rScO2) measurements. They hypothesized that previously reported contradictory results regarding the equivalence of SmvO2 and rScO2 might be related to time delay issues and to the measurement technology.
42 consenting patients undergoing elective off-pump coronary artery bypass grafting were included. 4 disposable oxygenation sensors were applied bilaterally on the patient's forehead for continuous, non-invasive registration of rScO2. The sensors of one monitor were placed just above the eyebrows, and the sensors of the other monitor were placed just above the former sensors. The sensors placement was determined at random by a computerized randomization list. SmvO2 was measured continuously via a pulmonary artery catheter. All variables were recorded continuously. The study ended at the end of the operation.
|Condition or disease||Intervention/treatment|
|Elective Off-pump Coronary Artery Bypass Grafting.||Procedure: Relative and absolute cerebral oxygen saturation (rScO2) measurements.|
|Study Type :||Observational|
|Actual Enrollment :||42 participants|
|Official Title:||Relation Between Mixed Venous Oxygen Saturation and Cerebral Oxygen Saturation Measured by Absolute and Relative Near-infrared Spectroscopy During Off-pump Coronary Artery Bypass Grafting.|
|Study Start Date :||October 2009|
|Actual Primary Completion Date :||June 2011|
|Actual Study Completion Date :||June 2011|
|Relative + absolute cerebral oxygen saturation.||
Procedure: Relative and absolute cerebral oxygen saturation (rScO2) measurements.
- Correlation and time delay between mixed venous and cerebral oxygen saturation during off-pump coronary artery bypass grafting. [ Time Frame: 4 hours during an operation of average 5 hours (during off-pump coronary artery bypass grafting). ]Mixed venous oxygen saturation was measured continuously via a pulmonary artery catheter. Cerebral oxygen saturation was measured with near-infrared spectroscopy; the INVOS monitor to obtain relative measurements, and the Foresight monitor to obtain absolute data.
- The response of cerebral oxygen saturation to major haemodynamic disturbances. [ Time Frame: 2 hours after start of operation (during placement of deep pericardial stitches). ]Percentage difference between the cerebral oxygen saturation value just before heart retraction and the value at the different time moments.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01673841
|Ghent University Hospital|
|Ghent, Belgium, 9000|
|Principal Investigator:||Annelies Moerman, MD||University Hospital, Ghent|