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Progranulin and CTRP3 in Metabolic Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01668888
Recruitment Status : Completed
First Posted : August 20, 2012
Last Update Posted : August 20, 2012
Information provided by (Responsible Party):
K. M. Choi, Korea University

Brief Summary:
Inflammation has been known to be a pivotal pathogenic mechanism of obesity-related disorders such as type 2 diabetes, metabolic syndrome and atherosclerosis. Adipose tissue functions as a major endocrine organ by adipokine mediated modulation of a number of signaling cascades in target tissues, that has pro-inflammatory or anti-inflammatory activities. Progranulin and CTRP3 are recently discovered novel adipokines. Therefore, the investigators tried to clarify the clinical meaning of these two adipokines in the subjects with or without metabolic syndrome

Condition or disease
Metabolic Syndrome

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Study Type : Observational
Actual Enrollment : 127 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Study Start Date : May 2012
Actual Primary Completion Date : August 2012
Actual Study Completion Date : August 2012

Resource links provided by the National Library of Medicine

Apparently Helathy Subjects

Primary Outcome Measures :
  1. Serum concentration of progranulin in the subjects with metabolic syndrome [ Time Frame: 12week ]
  2. Serum concentration of CTRP3 in the subjects with metabolic syndrome [ Time Frame: 12week ]

Secondary Outcome Measures :
  1. The relationship of serum progranulin levels with cardiovascular risk factors [ Time Frame: 12 week ]
  2. The relationship of serum CTRP3 levels with cardiovascular risk factors [ Time Frame: 12 week ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.

Inclusion Criteria:

  • 20<age<80
  • apparently healthy subjects

Exclusion Criteria:

  • a history of CVD
  • diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01668888

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Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Korea University

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: K. M. Choi, Professor, Korea University Identifier: NCT01668888     History of Changes
Other Study ID Numbers: KoreaHealth_Progranulin
First Posted: August 20, 2012    Key Record Dates
Last Update Posted: August 20, 2012
Last Verified: August 2012

Additional relevant MeSH terms:
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Metabolic Syndrome
Pathologic Processes
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases