Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study (ALSCELL)
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|ClinicalTrials.gov Identifier: NCT01639391|
Recruitment Status : Completed
First Posted : July 12, 2012
Last Update Posted : May 1, 2018
Patients with ALS will be included in the reference center for ALS in hospital La Pitié Salpêtrière, Paris.
The study proposes to investigate the pathophysiology of ALS by setting up a fibroblast bank for studying molecular, cellular and genetic parameters of the pathology.
iPS (induced pluripotent stem cells) and then differentiated cells will be generated.
The pathophysiology of ALS will be studied on the 3 types of cells (fibroblasts, iPS, differentiated cells).
|Condition or disease||Intervention/treatment||Phase|
|Amyotrophic Lateral Sclerosis||Procedure: skin biopsy||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||19 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study|
|Actual Study Start Date :||November 29, 2012|
|Actual Primary Completion Date :||March 17, 2015|
|Actual Study Completion Date :||March 17, 2015|
Procedure: skin biopsy
biopsy 5mm maximum on healthy skin under local anaesthesia.
- Success of fibroblast culture, amplification, and freezing pellets [ Time Frame: 2 months ]
- Induced pluripotent Stem Cells generation success [ Time Frame: 2 years ]
- neurones, motoneurones, glial cells obtention from fibroblasts or iPS [ Time Frame: 2 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01639391
|Centre référent maladies rares SLA|
|Paris, France, 75013|
|Principal Investigator:||Lucette Lacomblez, MD||hôpital La Pitié Salpêtrière, Paris|
|Study Chair:||Delphine Bohl, PhD||Institut Pasteur|