A PET Study to Determine Alterations in Serotonin Levels in Human Brain After a Single Dose of Escitalopram
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Healthy males were examined with positron emission tomography (PET) and the radioligand 11C-AZ10419369, before and after administration of a single dose escitalopram. A change in the binding potential of 11C-AZ10419369 between the baseline and the post-dose condition was hypothesized to reflect a change in serotonin concentration.
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Layout table for eligibility information
Ages Eligible for Study:
20 Years to 30 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Signed informed consent
Age 20 to 30 years
Healthy according to physical examination, ECG, MRI and blood chemistry
Past or present psychiatric disease
Past or present brain disorder or injury, including loss of consciousness for more than five minutes
Past or present drug or alcohol abuse
Past or present use of antidepressant or antipsychotic medications
Regular use of medications (including herbals), that could interfere with the pharmacodynamics or pharmacokinetics of escitalopram
Significant abnormality on ECG
Structural abnormality in the brain confirmed by MR examination
Any metal devises or implants in the body
Intolerance to escitalopram or any of the components of the formula
Predisposition to motion sickness
Inability to understand and comply with the study requirements
Any medical condition that, in the opinion of the investigator, make the subject unsuitable for the study or put the subject at additional risk