Aspirin Versus Clopidogrel Effect on Uterine Blood Flow in Women With Unexplained Recurrent Miscarriages
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ClinicalTrials.gov Identifier: NCT01635426 |
Recruitment Status : Unknown
Verified March 2017 by Mohamed Ellaithy, Ain Shams University.
Recruitment status was: Recruiting
First Posted : July 9, 2012
Last Update Posted : March 10, 2017
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The study will compare the effect of Aspirin versus clopidogrel effect on uterine perfusion in women with unexplained recurrent pregnancy loss with decreased uterine artery pulsatility index.
Null hypothesis: Women with recurrent miscarriage have the same blood flow after aspirin or clopidogrel treatment compared to their uterine artery pulsatility index before treatment.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Recurrent Pregnancy Loss | Drug: Aspirin Drug: Clopidogrel | Phase 2 Phase 3 |

Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 32 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Care Provider) |
Primary Purpose: | Treatment |
Official Title: | Aspirin Versus Clopidogrel Effect on Uterine Perfusion in Women With Unexplained Recurrent Pregnancy Loss With Decreased Uterine Artery Pulsatility Index: A Randomized Controlled Trial |
Study Start Date : | March 2012 |
Estimated Primary Completion Date : | January 2018 |
Estimated Study Completion Date : | March 2018 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Aspirin |
Drug: Aspirin
Aspirin 75 mg daily for 2 months after meals
Other Name: Acetylsalicylic Acid |
Active Comparator: Clopidogrel |
Drug: Clopidogrel
Clopidogrel 75 mg daily for 2 months after meals
Other Name: Plavix |
- Improvement in uterine artery pulsatility index [ Time Frame: 2 months ]
- Improvement in subendometrial blood flow [ Time Frame: 2 month ]

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Ages Eligible for Study: | 20 Years to 35 Years (Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Women aged between 20 to 38 years old.
- Regular menstrual cycle (26 to 33 days).
- Women with 2 or more previous unexplained first trimester miscarriage.
- Impaired uterine perfusion (PI of uterine artery more than 2.5).
Exclusion Criteria:
- Known hypersensitivity to any of study medication components.
- Immunotherapy, endocrinotherapy, anticoagulant or anti-platelet management during the past 3 months

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01635426
Contact: Mostafa I. Ibrahem, M.D. | 00201001955996 | mi_monem@yahoo.com |
Egypt | |
Ain Shams University | Recruiting |
Abbasiya, Cairo, Egypt, 11566 | |
Contact: Mohamed I. Ellaithy, M.D. 00201006873417 drmellisy@hotmail.com |
Principal Investigator: | Mohamed I Ellaithy, M.D. | Ain Shams University |
Responsible Party: | Mohamed Ellaithy, Lecturer of Obstetrics & Gynecology, Ain Shams University |
ClinicalTrials.gov Identifier: | NCT01635426 |
Other Study ID Numbers: |
ASUOGRCT976 |
First Posted: | July 9, 2012 Key Record Dates |
Last Update Posted: | March 10, 2017 |
Last Verified: | March 2017 |
Aspirin Clopidogrel Unexplained recurrent pregnancy loss Uterine artery pulsatility index |
Abortion, Spontaneous Fetal Death Abortion, Habitual Recurrence Disease Attributes Pathologic Processes Pregnancy Complications Death Aspirin Clopidogrel Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous System Agents |
Physiological Effects of Drugs Anti-Inflammatory Agents Antirheumatic Agents Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Platelet Aggregation Inhibitors Cyclooxygenase Inhibitors Enzyme Inhibitors Antipyretics Purinergic P2Y Receptor Antagonists Purinergic P2 Receptor Antagonists Purinergic Antagonists Purinergic Agents Neurotransmitter Agents |