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ClinicalTrials.gov Identifier: NCT01633450
Recruitment Status :
First Posted : July 4, 2012
Last Update Posted : June 7, 2013
Swiss Federal Institute of Technology
University of Zurich
Information provided by (Responsible Party):
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology
One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.
Condition or disease
Other: Zinc biofortified riceOther: Rice extrinsically fortified with zinc
Fractional absorption of zinc [ Time Frame: 33 days ]
Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 45 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Male or female of 18 to 45 years old
Body Mass Index in the range of 19 to 25
No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study
Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
Long-term medication during the whole study (except for contraceptives)
Intention to become pregnant during the course of the study
Lack of safe contraception
Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study