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Zinc Absorption From Biofortified Rice

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01633450
Recruitment Status : Completed
First Posted : July 4, 2012
Last Update Posted : June 7, 2013
University of Zurich
Information provided by (Responsible Party):
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology

Brief Summary:
One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.

Condition or disease Intervention/treatment Phase
Healthy Other: Zinc biofortified rice Other: Rice extrinsically fortified with zinc Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Official Title: Bioavailability of Zinc From Rice Biofortified With 70Zn and Rice Extrinsically Labeled With 70Zn in Young Adults: a Randomized, Single-blind Study
Study Start Date : June 2012
Actual Primary Completion Date : August 2012
Actual Study Completion Date : October 2012

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Zinc biofortified rice Other: Zinc biofortified rice
1.12 mg zinc per meal

Active Comparator: Rice extrinsically fortified with zinc Other: Rice extrinsically fortified with zinc
1.12 mg zinc per meal

Primary Outcome Measures :
  1. Fractional absorption of zinc [ Time Frame: 33 days ]
    Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male or female of 18 to 45 years old
  • Body Mass Index in the range of 19 to 25
  • No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria:

  • Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
  • Long-term medication during the whole study (except for contraceptives)
  • Pregnancy
  • Lactation
  • Intention to become pregnant during the course of the study
  • Lack of safe contraception
  • Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01633450

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ETH Zurich
Zurich, Switzerland
Sponsors and Collaborators
Swiss Federal Institute of Technology
University of Zurich

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology Identifier: NCT01633450     History of Changes
Other Study ID Numbers: HNL/CTC12-Reis
First Posted: July 4, 2012    Key Record Dates
Last Update Posted: June 7, 2013
Last Verified: June 2013
Additional relevant MeSH terms:
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Trace Elements
Growth Substances
Physiological Effects of Drugs