Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder
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ClinicalTrials.gov Identifier: NCT01631851 |
Recruitment Status :
Active, not recruiting
First Posted : June 29, 2012
Last Update Posted : January 13, 2020
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Autism Autism Spectrum Disorder (ASD Asperger's Disorder Pervasive Developmental Disorder (PDD-NOS) | Behavioral: Cognitive-Behavioral Therapy (CBT) for Irritability | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 10 participants |
Allocation: | N/A |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Official Title: | Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder |
Study Start Date : | May 2011 |
Estimated Primary Completion Date : | December 2020 |
Estimated Study Completion Date : | December 2020 |

Arm | Intervention/treatment |
---|---|
Experimental: Cognitive behavior therapy |
Behavioral: Cognitive-Behavioral Therapy (CBT) for Irritability
CBT is an individually administered behavioral interventions aimed at reducing irritability and disruptive behavior. There are 10 to 12 weekly sessions that are conducted with the child and the parent. During these sessions children are taught to recognize antecedents and consequences of problem behavior and to use emotion regulation and problem-solving skills to reduce irritability, aggression and noncompliance.
Other Name: Anger Control Training |
- ABC Irritability Scale [ Time Frame: 1 week ]Parent rating of irritability and disruptive behavior that has been often used in studies with children with ASD

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Ages Eligible for Study: | 9 Years to 16 Years (Child) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- DSM-IV diagnosis of autistic disorder, Asperger's disorder, or PDD-NOS
- presence of disruptive behaviors such as irritability and anger outbursts
- IQ above 80
- Unmedicated or on stable medication
Exclusion Criteria:
- medical or psychiatric condition that would require alternative treatment

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01631851
United States, Connecticut | |
Yale Child Study Center | |
New Haven, Connecticut, United States, 06520 |
Principal Investigator: | Denis Sukhodolsky, Ph.D. | Yale University, Child Study Center |
Responsible Party: | Denis Sukhodolsky, Research Scientist, Yale University |
ClinicalTrials.gov Identifier: | NCT01631851 |
Other Study ID Numbers: |
0102012121-B |
First Posted: | June 29, 2012 Key Record Dates |
Last Update Posted: | January 13, 2020 |
Last Verified: | January 2020 |
Autism Irritability Disruptive Behavior |
Aggression Behavior Therapy Cognitive Behavioral Therapy |
Disease Autistic Disorder Autism Spectrum Disorder Child Development Disorders, Pervasive Developmental Disabilities |
Asperger Syndrome Pathologic Processes Neurodevelopmental Disorders Mental Disorders |