Vitamin D Supplementation in Obesity and Weight Loss (3DD Study)
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ClinicalTrials.gov Identifier: NCT01631292
Recruitment Status : Unknown
Verified January 2019 by Sue Shapses, Rutgers University. Recruitment status was: Active, not recruiting
In this study, we will provide supplemental vitamin D in postmenopausal overweight/obese women, and hypothesize that it will not affect areal BMD, but will alter bone compartments (trabecular and cortical bone). In addition, higher vitamin D intake will increase serum 25OHD and suppress serum PTH and bone turnover during weight reduction. Secondary outcomes include the influence of vitamin D and weight loss on markers of insulin resistance and on cognitive tests of attention, learning, and memory.
Condition or disease
Dietary Supplement: 600 IU Vitamin D3Dietary Supplement: 2000 IU Vitamin D3Dietary Supplement: 4000 IU Vitamin D3
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Layout table for eligibility information
Ages Eligible for Study:
50 Years to 72 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Body mass index of 25-40 kg/m2,
Age 50-72 years.
Women who are taking any medication known to influence Ca or bone metabolism, or with evidence of diseases known to influence Ca metabolism (i.e. metabolic bone disease, hyperparathyroidism, untreated thyroid disease, significant immune, hepatic, or renal disease, a kidney stone in the last 5 yrs., significant cardiac disease, active malignancy or cancer therapy within the past year) are not eligible.