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The Effect of a Meal on Brain Activation in Reward Pathways (Satiety)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01631045
Recruitment Status : Completed
First Posted : June 28, 2012
Last Update Posted : July 4, 2013
Information provided by (Responsible Party):
Ellen Schur, MD, MS, University of Washington

Brief Summary:
Scientists have studied how fasting and nutrients affect brain function in animals. The purpose of this study is to look at the effects of both fasting and food intake on brain function and memory in humans. To do this the investigators will use functional MRI to observe the brain and its function while fasting and after a meal. Understanding the action of these hormones in the brain may eventually lead to new ways to help people avoid obesity or lose weight.

Condition or disease
Brain Response to Visual Food Cues

Detailed Description:
Potential subjects will participate in a short phone screening interview and if eligible, will come to the University of Washington hospital 2 times. At the first health screening visit, we will go over the subjects' medical history, weight and height, and eating habits. This visit will take an hour or so and eligible subjects will then schedule the study visit. For the study visit, subjects will have to fast overnight from 9:30 pm the night before and arrive at the hospital at 8:00am. At 8:30 am, the subject will have a 30 minute MRI scan of the brain done in the University of Washington Radiology Department. During the MRI scan they will see pictures of common objects and foods and be asked to remember the photos they saw. At 9 am subjects will eat a standard breakfast, and they will not eat again until after the second MRI. The time of their second MRI will be randomly assigned to one of seven time points anywhere from 15 minutes to 5 hours after the breakfast. After the MRI, subjects will be allowed to eat freely from food we provide. Subjects will receive $10 for the health screening visit, and $50-85 depending on the length of the visit.

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Study Type : Observational
Actual Enrollment : 24 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: The Effect of a Meal on Brain Activation in Reward Pathways
Study Start Date : April 2010
Actual Primary Completion Date : June 2012
Actual Study Completion Date : June 2012

15 min
Subjects post-meal brain MRI will be 15 minutes after breakfast.
30 min
Subjects post-meal brain MRI will be 30 minutes after breakfast.
Subjects post-meal brain MRI will be 60 minutes after breakfast.
Subjects post-meal brain MRI will be 120 minutes after breakfast.
Subjects post-meal brain MRI will be 180 minutes after breakfast.
Subjects post-meal brain MRI will be 240 minutes after breakfast.
Subjects post-meal brain MRI will be 300 minutes after breakfast.

Primary Outcome Measures :
  1. BOLD response as measured by brain fMRI during viewing of food photographs [ Time Frame: We will randomly assign subjects to one of 7 timepoints for a post-meal brain MRI - 15, 30, 60, 120, 180, 240, or 300 minutes after their breakfast. ]
    To determine whether the change in brain response (as captured by MRI) to visual food cues with food intake is a marker of satiety. We hypothesize that consumption of a meal will reduce brain activation by food cues and that these reductions will be temporally associated with both subjective and objective measures of satiety.

Secondary Outcome Measures :
  1. Secondary endpoints are the amount of food eaten at a lunch buffet and self-reported appetite ratings. [ Time Frame: Every 30 minutes throughout study. ]
    To measure subjective appetite and satiety, subjects will complete serial visual analog rating scales (VAS) of hunger and fullness every 30 minutes. We predict that the percentage change in brain activation will correlate with changes in self-reported hunger and fullness. After the post-meal scan, we will obtain measurements of objective satiety for each subject by monitoring his or her food intake during a 30 minute ad libitum buffet meal. The buffet will be surreptitiously monitored, allowing us to assess ad libitum caloric intake and food choices.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
We will enroll 21 healthy subjects. Participants will be recruited by flyers posted at the University and by newspaper advertisements.

Inclusion Criteria:

  1. Age 18-50
  2. Body mass index (BMI) 18.5-24.9 kg/m2

    • Age and weight are restricted because of known changes in appetite and satiety with aging and changes in body weight.

Exclusion Criteria:

  1. Current dieting for weight loss or restrained eating
  2. History of eating disorders, prior obesity, or weight loss surgery
  3. Chronic health conditions, including diabetes
  4. Use of medications that alter appetite (e.g., atypical anti-psychotics)
  5. Pregnancy or use of oral contraceptives of estrogen replacement
  6. Participation in other studies that might affect appetite or body weight
  7. Recreational drug use or alcohol use of >2 drinks per day
  8. Food allergies to study foods or inability to taste
  9. Current smoker
  10. Any contraindications to MRI such as implanted metal of claustrophobia

    • Current dieting, restrained eating, eating disorders, prior weight loss surgery, diabetes, chronic disease (e.g., cardiovascular disease, cancer), and estrogen use are restricted or excluded due to documented influences on the hormones of interest. Smokers and regular alcohol users are excluded consistent with prior studies of appetite regulation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01631045

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United States, Washington
University of Washington Medical Center
Seattle, Washington, United States, 98104
Sponsors and Collaborators
University of Washington
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Principal Investigator: Ellen Schur, MD, MS Assistant Professor
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Ellen Schur, MD, MS, Assistant Professor, University of Washington Identifier: NCT01631045    
Other Study ID Numbers: 38022
First Posted: June 28, 2012    Key Record Dates
Last Update Posted: July 4, 2013
Last Verified: July 2013
Keywords provided by Ellen Schur, MD, MS, University of Washington: