The Effect of a Meal on Brain Activation in Reward Pathways (Satiety)
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ClinicalTrials.gov Identifier: NCT01631045 |
Recruitment Status :
Completed
First Posted : June 28, 2012
Last Update Posted : July 4, 2013
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Condition or disease |
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Brain Response to Visual Food Cues |
Study Type : | Observational |
Actual Enrollment : | 24 participants |
Observational Model: | Case-Control |
Time Perspective: | Cross-Sectional |
Official Title: | The Effect of a Meal on Brain Activation in Reward Pathways |
Study Start Date : | April 2010 |
Actual Primary Completion Date : | June 2012 |
Actual Study Completion Date : | June 2012 |
Group/Cohort |
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15 min
Subjects post-meal brain MRI will be 15 minutes after breakfast.
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30 min
Subjects post-meal brain MRI will be 30 minutes after breakfast.
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60
Subjects post-meal brain MRI will be 60 minutes after breakfast.
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120
Subjects post-meal brain MRI will be 120 minutes after breakfast.
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180
Subjects post-meal brain MRI will be 180 minutes after breakfast.
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240
Subjects post-meal brain MRI will be 240 minutes after breakfast.
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300
Subjects post-meal brain MRI will be 300 minutes after breakfast.
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- BOLD response as measured by brain fMRI during viewing of food photographs [ Time Frame: We will randomly assign subjects to one of 7 timepoints for a post-meal brain MRI - 15, 30, 60, 120, 180, 240, or 300 minutes after their breakfast. ]To determine whether the change in brain response (as captured by MRI) to visual food cues with food intake is a marker of satiety. We hypothesize that consumption of a meal will reduce brain activation by food cues and that these reductions will be temporally associated with both subjective and objective measures of satiety.
- Secondary endpoints are the amount of food eaten at a lunch buffet and self-reported appetite ratings. [ Time Frame: Every 30 minutes throughout study. ]To measure subjective appetite and satiety, subjects will complete serial visual analog rating scales (VAS) of hunger and fullness every 30 minutes. We predict that the percentage change in brain activation will correlate with changes in self-reported hunger and fullness. After the post-meal scan, we will obtain measurements of objective satiety for each subject by monitoring his or her food intake during a 30 minute ad libitum buffet meal. The buffet will be surreptitiously monitored, allowing us to assess ad libitum caloric intake and food choices.

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Age 18-50
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Body mass index (BMI) 18.5-24.9 kg/m2
- Age and weight are restricted because of known changes in appetite and satiety with aging and changes in body weight.
Exclusion Criteria:
- Current dieting for weight loss or restrained eating
- History of eating disorders, prior obesity, or weight loss surgery
- Chronic health conditions, including diabetes
- Use of medications that alter appetite (e.g., atypical anti-psychotics)
- Pregnancy or use of oral contraceptives of estrogen replacement
- Participation in other studies that might affect appetite or body weight
- Recreational drug use or alcohol use of >2 drinks per day
- Food allergies to study foods or inability to taste
- Current smoker
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Any contraindications to MRI such as implanted metal of claustrophobia
- Current dieting, restrained eating, eating disorders, prior weight loss surgery, diabetes, chronic disease (e.g., cardiovascular disease, cancer), and estrogen use are restricted or excluded due to documented influences on the hormones of interest. Smokers and regular alcohol users are excluded consistent with prior studies of appetite regulation.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01631045
United States, Washington | |
University of Washington Medical Center | |
Seattle, Washington, United States, 98104 |
Principal Investigator: | Ellen Schur, MD, MS | Assistant Professor |
Responsible Party: | Ellen Schur, MD, MS, Assistant Professor, University of Washington |
ClinicalTrials.gov Identifier: | NCT01631045 |
Other Study ID Numbers: |
38022 |
First Posted: | June 28, 2012 Key Record Dates |
Last Update Posted: | July 4, 2013 |
Last Verified: | July 2013 |
Obesity |