Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy (CPAPandHCM)
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ClinicalTrials.gov Identifier: NCT01631006 |
Recruitment Status :
Completed
First Posted : June 28, 2012
Last Update Posted : December 19, 2014
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Condition or disease | Intervention/treatment | Phase |
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Non-obstructive Hypertrophic Cardiomyopathy Obstructive Hypertrophic Cardiomyopathy | Device: CPAP | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 26 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Investigator) |
Primary Purpose: | Treatment |
Official Title: | Acute Hemodynamic Effects of Continous Positive Airway Pressure (CPAP) in Patients With Hypertrophic Cardiomyopathy |
Study Start Date : | January 2012 |
Actual Primary Completion Date : | December 2012 |
Actual Study Completion Date : | April 2013 |

Arm | Intervention/treatment |
---|---|
Sham Comparator: Low CPAP pressure
Patients are submmited to a CPAP with low pressure for 20 minutes
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Device: CPAP
A low or high CPAP pressure is delivered for 20 minutes |
Active Comparator: High CPAP pressure
Patients are submmited to a high pressure of CPAP for 20 minutes
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Device: CPAP
A low or high CPAP pressure is delivered for 20 minutes |
- Cadiac performance by echocardiography [ Time Frame: acutely ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- both genders
- over 18 years-old
- hemodynamically stable
- with no other cardiac disease
- consent form signed
Exclusion Criteria:
- presence of pacemaker
- spontaneous withdrawal
- previous cardiorespiratory arrest
- atrial fibrilation during echocardiography

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01631006
Brazil | |
Heart Institute | |
Sao Paulo, Brazil, 05403000 |
Responsible Party: | Geraldo Lorenzi-Filho, Associated Professor of Pulmonary Division, University of Sao Paulo |
ClinicalTrials.gov Identifier: | NCT01631006 |
Other Study ID Numbers: |
SDC 325209/003 |
First Posted: | June 28, 2012 Key Record Dates |
Last Update Posted: | December 19, 2014 |
Last Verified: | December 2014 |
CPAP Hypertrophic cardiomyopathy Blood Pressure The focus of the present study is to evaluate the acute hemodynamic effects of CPAP in patients with non-obstructive and obstructive hypertrophic cardiomyopathy |
Cardiomyopathies Cardiomyopathy, Hypertrophic Hypertrophy Heart Diseases Cardiovascular Diseases |
Pathological Conditions, Anatomical Aortic Stenosis, Subvalvular Aortic Valve Stenosis Heart Valve Diseases |